Genomics-based multimodal model to predict post-stroke vascular dementia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects large-scale data from stroke survivors and healthy controls, including genomic data, MRI, EEG, fNIRS, and cognitive assessments over time. The goal is to develop and validate an integrated model that predicts elevated risk of post-stroke vascular dementia and supports precision medicine in stroke-related cognitive impairment. Participants are enrolled from subacute to chronic stages after stroke and followed longitudinally to track cognitive and functional changes. The study aims to improve risk stratification and enable targeted monitoring and interventions based on multimodal biomarkers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Healthy Control Group:

   * Adults aged 19 years or older.
   * Able to be age- and sex-matched to the stroke cohort.
   * No history of stroke, transient ischemic attack (TIA), or other central nervous system disorders.
   * Cognitive function within the normal range for age and education level based on screening assessments (K-MMSE and K-MoCA).
   * Able to understand the study procedures and provide written informed consent.
2. Stroke Patient Group:

   * Adults aged 19 years or older.
   * First-ever ischemic or hemorrhagic stroke confirmed by CT or MRI.
   * Enrolled in one of the following strata according to time since stroke onset:

Stratum A: 7 days to 3 months after stroke onset. Stratum B: \>3 months to 12 months after stroke onset. Stratum C: \>12 months to 36 months after stroke onset.

\- Able to understand the study procedures and provide written informed consent, or consent provided by a legally authorized representative when applicable.

Exclusion Criteria:

1. Healthy Control Group:

   * Current severe psychiatric disorders that may affect cognitive function (e.g., major depression, schizophrenia) or use of related medications.
   * Strong family history of hereditary cerebrovascular disorders (e.g., CADASIL).
   * Severe medical illness considered inappropriate for study participation.
   * Any condition that, in the opinion of the investigator, would make participation unsuitable.
2. Stroke Patient Group:

   * Impaired ability to provide consent (MMSE \<10) without an accompanying caregiver or legally authorized representative.
   * History of dementia due to causes other than stroke (e.g., Alzheimer's disease) prior to stroke onset.
   * History of major neurological disorders affecting cognition prior to stroke onset (e.g., Parkinson's disease, brain tumor, multiple sclerosis).
   * Severe aphasia or impaired consciousness preventing completion of cognitive assessments.
   * Current or pre-stroke severe psychiatric disorders that may affect cognitive function (e.g., major depression, schizophrenia) or use of related medications.
   * Strong family history of hereditary cerebrovascular disorders (e.g., CADASIL).
   * Contraindication to MRI (e.g., metallic implants) or refusal to provide blood samples for genomic analysis.
   * Any condition that, in the opinion of the investigator, would make participation unsuitable.

Where it's running

• Bundang CHA Medical Center
  Gyeonggi-do, Gyeonggi-do, South Korea Recruiting

Study contacts

• Study coordinator: Seyoung Shin, MD
• Email: seyoung0706@chamc.co.kr
• Phone: +82437505000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.