Genicular nerve ablation before geniculate artery embolization for knee pain relief
Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain Management: A Randomized Controlled Trial
This study is testing if doing a nerve treatment before a knee artery procedure can help people with chronic knee pain feel better and improve their knee function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Zagazig University Government |
| Locations | 1 site (Zagazig) |
| Trial ID | NCT06514755 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of performing genicular nerve ablation (GNA) prior to geniculate artery embolization (GAE) in patients suffering from chronic knee pain. Participants will be divided into two groups: one receiving GNA followed by GAE and the other receiving GAE alone. The study aims to measure pain relief using the Visual Analog Scale (VAS) and assess knee function through the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at various follow-up intervals. Additionally, patient satisfaction will be evaluated through a structured questionnaire at three months post-procedure.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 80 with chronic knee pain that has not responded to conservative treatments.
Not a fit: Patients with contraindications to the procedures, recent knee surgery, or severe comorbid conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain relief and knee function for patients with chronic knee pain.
How similar studies have performed: While the individual procedures have been studied, the sequential approach of GNA followed by GAE is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 to 80 years. * Diagnosed with chronic knee pain refractory to conservative treatment. * Able to provide informed consent. * Agree to follow the study procedures and attend follow-up visits. Exclusion Criteria: * Contraindications to GNA or GAE procedures (e.g., allergy to local anesthetics, active infection at the procedure site). * Recent knee surgery within the last six months. * Severe comorbid conditions that may interfere with the study outcomes (e.g., rheumatoid arthritis, other severe autoimmune diseases). * Current participation in another clinical trial that could interfere with the outcomes of this study.
Where this trial is running
Zagazig
- Zagazig University, Faculty of Medicine — Zagazig, Egypt (Recruiting)
Study contacts
- Principal investigator: Ahmed A Bessar, MD, PhD — Assistant Professor of Diagnostic and Interventional Radiology, Zagazig Uni.
- Study coordinator: Ahmed A Bessar, MD, PhD
- Email: Ahmedawadbessar@gmail.com
- Phone: +201000089595
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.