Genetic analysis of heart muscle diseases
Genetic Characterization of Cardiomyopathies (POLICARDIOMIO2021)
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · NCT05556369
This study is testing how genetic testing can help people with heart muscle diseases and their family members understand their risks better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 288 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (other) |
| Locations | 1 site (Milan, Lombardy) |
| Trial ID | NCT05556369 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the genetic characterization of various types of cardiomyopathies, which are diseases affecting the heart muscle. It aims to improve risk stratification for patients diagnosed with structural cardiomyopathy and their first-degree relatives through genetic testing. The study will involve participants who have been diagnosed with specific types of cardiomyopathy, allowing researchers to gather data on genetic factors associated with these conditions. By understanding the genetic underpinnings, the study seeks to enhance clinical management and familial risk assessment.
Who should consider this trial
Good fit: Ideal candidates for this study include individuals diagnosed with structural cardiomyopathy and their first-degree relatives.
Not a fit: Patients over the age of 80 or those with conditions that sufficiently explain their cardiomyopathy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients with cardiomyopathies and their families.
How similar studies have performed: Other studies have shown success in using genetic testing for risk stratification in cardiomyopathies, indicating that this approach is supported by existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presence of structural cardiomyopathy * First degree relatives for cardiomyopathy Exclusion Criteria: * Age \> 80 * Presence of sufficient conditions to explain the clinical condition of cardiomyopathy * Peripartum cardiomyopathy
Where this trial is running
Milan, Lombardy
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico — Milan, Lombardy, Italy (RECRUITING)
Study contacts
- Study coordinator: Stefano Carugo, Principal Investigator
- Email: stefano.carugo@policlinico.mi.it
- Phone: +39 0255033579
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiomyopathies, Cardiomyopathy, Hypertrophic, Dilated, ARVD, Restrictive, NGS, Gene mutation