Gait adaptability in people with mild multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study will recruit 16 adults with mild MS (EDSS 0–3.5) and 16 age- and sex-matched healthy controls for a single in-person testing session at Hasselt University's REVAL center. Participants will complete timed motor tests (e.g., Timed 25‑Foot Walk, Six-Spot Step Test, 6‑Minute Walk), balance assessments (Mini-BESTest), cognitive tests (SDMT, BVMT-R), and self-report questionnaires on fatigue, walking, and balance confidence. Proactive gait adaptability will be probed using an overground Walking Adaptability Ladder Test with progressively smaller stepping targets, while wearable movement sensors record kinematics; reactive responses will be examined with appropriate perturbation and obstacle tasks. Data will be compared between groups to characterize adaptability deficits and their relationships with fatigue, cognition, and fall-related measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18-65 years,
* confirmed diagnosis of definite MS,
* relapse free at least 30 days,
* Expanded Disability Status Scale (EDSS) score between 0 and 3.5

Exclusion Criteria:

* Diagnosed with neurological disease other than MS
* cognitive decline that renders the patient incapable of performing tests and questionnaires.
* Other neurological, orthopedic, or visual impairments affecting gait

Where it's running

• REVAL Rehabilitation Research Center, University of Hasselt
  Diepenbeek, Belgium Recruiting

Study contacts

• Study coordinator: Zuhal Abasiyanik, PhD
• Email: zuhal.abasiyanik@uhasselt.be
• Phone: +32(0)11 26 93 06

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Treadmill-based virtual reality walking training for MS patients

  This study tests whether a treadmill with virtual reality and smart socks can help people with multiple sclerosis walk better and feel safer in daily life.

  Recruiting Shepherd Center, Atlanta GA · Atlanta, Georgia · NCT07927439

• Virtual Reality and Mental Practice to Improve Balance and Walking in Relapsing MS

  This study tests whether virtual reality training or mental practice can improve balance and walking in people with relapsing–remitting multiple sclerosis.

  Recruiting Cairo University · Giza, Giza Governorate · NCT07918339

• REAL-MS: A Look at Autologous Stem Cell Transplant vs High-Efficacy MS Therapies in Real-World Care

  This study tests how AHSCT compares to high-efficacy MS medicines in adults treated in routine clinical care.

  Recruiting Imperial College London · London and 2 other locations · NCT07899502

• Tolebrutinib in real-world MS care for patients treated by clinicians

  This real-world study sees how tolebrutinib is used for multiple sclerosis patients and what outcomes look like in everyday practice.

  Recruiting Sanofi · Marina, Abu Dhabi Emirate · NCT07898371

• Pilates via live video vs. prerecorded videos for people with multiple sclerosis

  This study tests whether live, coach-led Pilates sessions through video calls are more beneficial than prerecorded Pilates videos for adults with MS.

  Recruiting Yuzuncu Yil University · Van · NCT07893925

• Cooling During Inpatient Rehab for People with MS

  This trial tests whether wearing a cooling vest during intensive training can reduce fatigue and improve walking, strength, balance, and cognition in people with multiple sclerosis during a 3-week inpatient rehab stay.

  Recruiting Klinik Valens · Valens, Canton of St. Gallen · NCT07852156

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.