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French nationwide registry of colorectal endoscopic submucosal dissection at expert centers

French Colorectal ESD Cohort in Experts Centers

Observational University Hospital, Limoges · NCT04592003

We will collect outcomes from patients referred for colorectal endoscopic submucosal dissection (ESD) at expert French centers to see how safe and effective ESD is for removing large superficial colorectal lesions.

Quick facts

Study typeObservational
Enrollment1200 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity Hospital, Limoges Academic / other
Locations25 sites (Amiens and 24 other locations)
Trial IDNCT04592003 on ClinicalTrials.gov

What this trial studies

This multicenter observational cohort will enroll all patients referred for colorectal ESD at participating French expert centers and prospectively record procedural, histological, safety, and follow-up outcomes. Data collected will include en bloc resection and recurrence rates, perforation and bleeding complications, procedure duration, and need for repeat interventions or surgery. The project aims to provide large-scale, real-world evidence on safety, effectiveness, and practice patterns of colorectal ESD across France compared with published benchmarks for wide-field EMR. As an observational registry, it will describe outcomes and variation in practice rather than provide randomized comparisons.

Who should consider this trial

Good fit: Ideal candidates are adults referred for colorectal ESD for large superficial neoplastic or pre-neoplastic colorectal lesions.

Not a fit: Patients with invasive colorectal cancer requiring surgery, those not referred for or who decline ESD, or patients with contraindications to endoscopic resection are unlikely to benefit from participation.

Why it matters

Potential benefit: If successful, this registry could clarify the real-world safety and effectiveness of colorectal ESD and inform treatment choices for large superficial colorectal lesions.

How similar studies have performed: Japanese series have shown high en bloc resection rates and low recurrence with ESD, but prospective comparative data in Western populations are limited.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

All patients addressed for a colorectal ESD

Exclusion Criteria:

Opposition notified in the context of a non-opposition form after reading the information notice

Where this trial is running

Amiens and 24 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Cancer ColorectalPolyps ColorectalEndoscopic Submucosal ResectionCancer colorectalPolyps colorectalEndoscopic submucosal resection
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.