Fluid choice during heart surgery: comparing HES to crystalloids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 4 interventional trial comparing two intraoperative fluids—Volulyte HES 6% and balanced crystalloids—in adults undergoing CABG, valve, or thoracic aortic surgery. The study measures major adverse kidney events after surgery to see which fluid approach maintains kidney function better. The trial uses standard intraoperative fluid administration aimed at preload and intravascular volume support. Participants are monitored for safety and kidney outcomes through postoperative follow-up.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 19 years or older scheduled for coronary artery bypass grafting (CABG), heart valve surgery, and/or thoracic aortic surgery

Exclusion Criteria:

1. Emergency surgery;
2. Planned implantation of a durable left ventricular assist device;
3. History of starch allergy or hypersensitivity;
4. History of kidney transplantation;
5. Preoperative end-stage renal disease (ESRD) or requirement for renal replacement therapy (RRT);
6. Preoperative glomerular filtration rate \< 30 mL/min/1.73 m2;
7. Planned intraoperative and postoperative RRT;
8. Preoperative use of mechanical circulatory support devices (e.g., intra-aortic balloon pump, extracorporeal membrane oxygenation, etc.);
9. Significant clinical coagulopathy (e.g., active bleeding disorder or thrombocytopenia with a platelet count \<100,000/µL);
10. Active infective endocarditis.

Where it's running

• Chungnam National University Hospital
  Daejeon, South Korea Recruiting
• Korea University Guro Hospital
  Seoul, South Korea Recruiting
• Seoul National University Hospital
  Seoul, South Korea Recruiting
• Severance Hospital
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Karam Nam, M.D., Ph.D.
• Email: karamnam@gmail.com
• Phone: +82 2 2072 0643

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.