Finding the blocked artery in medium-vessel stroke using multiple CT scans
Study on the Accuracy of Determining the Responsible Vessel in Medium Vessel Occlusive Stroke Based on Multi-type CT Evaluation
We will see if using multiple types of CT scans (noncontrast CT, CTA, and CT perfusion) can accurately identify the specific artery causing a medium-vessel ischemic stroke in adults within 24 hours of symptom onset.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 622 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT07347587 on ClinicalTrials.gov |
What this trial studies
This is an observational imaging study enrolling adults with acute ischemic stroke who received pre-treatment noncontrast CT, CT angiography (CTA), and CT perfusion (CTP) within 24 hours of last-well time. Original CTP images will be post-processed and multimodal CT data (including DICOM files) will be reviewed to determine the responsible vessel in cases of medium-vessel occlusion. Cases with complete clinical and imaging records will be included, while those with intracranial hemorrhage or unusable image data will be excluded. The accuracy of artery attribution by multimodal CT will be compared with available clinical imaging records and follow-up imaging when available.
Who should consider this trial
Good fit: Adults aged 18 or older with acute ischemic stroke, treated within 24 hours of last-well time, who had pre-treatment CT, CTA, and CTP with complete clinical and DICOM imaging data are ideal candidates.
Not a fit: Patients with acute intracranial hemorrhage, poor-quality or missing DICOM imaging files, or CTP images that cannot be post-processed are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this approach could help clinicians more quickly and precisely identify the specific artery causing a medium-vessel stroke, which may improve selection and planning of treatments.
How similar studies have performed: Multimodal CT and CT perfusion have been useful for identifying large-vessel occlusions, but their specific accuracy for pinpointing responsible arteries in medium-vessel occlusion is less well-established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with acute ischemic stroke, without restrictions on gender * Age ≥ 18 years old * The time from onset to treatment is within 24 hours (the onset time is defined as the "last-well-time", and the treatment plan is determined according to the patient's wishes and local clinical experience) * Before the treatment, CT, CTA and CTP examinations were conducted, and the relevant clinical data were complete. Exclusion Criteria: * Patients with acute intracranial hemorrhage * Patients whose CTP original images cannot be processed by the CTP post-processing software * Patients for whom the DICOM format image data of CT, CTP original images and MRI images cannot be obtained, or whose image quality is poor due to various reasons
Where this trial is running
Beijing, Beijing Municipality
- Xuanwu Hospital Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Study coordinator: Shujuan Meng, MD
- Email: 1026012717@qq.com
- Phone: 01083198082
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.