Finding internal tremors with wearable sensors in people with Parkinson's

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will place inertial sensors (accelerometers) on participants and record for signatures of a rhythmic oscillation around 3–4 Hz that patients describe as an internal tremor. The protocol will enroll people with idiopathic Parkinson's disease in the OFF medication state and age- and sex-matched healthy controls to test specificity. Data will be analyzed to identify objective oscillatory patterns that match patients' subjective reports. The aim is to establish whether a measurable signal corresponding to internal tremor can be reliably detected using wearable devices.

Why it matters

Who can join: the full rules

Inclusion Criteria:

(For the experimental group)

* Patient with idiopathic parkinson's disease
* Mini Mental State Evaluation score above or equal to 25
* Hoehn and Yahr scale score of ≤3 in the OFF phase, with postural stability allowing the patient to stand unaided for 1 minute.
* Able to walk unassisted
* Willing to undergo accelerometry in the OFF state

(For the control group)

* Healthy volunteer subjects matched for age (+/- 5 years) and sex
* Mini Mental State Evaluation score above or equal to 25

Exclusion Criteria:

(For the experimental group)

* Patients with an atypical parkinsonian syndrome
* Patients unable to walk or stand for more than one minute in the off state
* Parkinson's patients treated with deep brain stimulation, apomorphine pump, or duodopa intestinal infusion, and foslevodopa
* Pregnant patients
* Major osteoarticular problems
* Neurological condition that may affect gait

(For the control group)

* Participants with significant gait impairment (osteoarticular disorder)
* Those with a neurological disease that, in the investigator's judgment, may interfere with the study's outcome measure
* Participants with a clinical tremor that may interfere with the measurement of the primary outcome (e.g., essential tremor, thyroid disease, or tremors induced by medication)
* Pregnant participants

Where it's running

• Purpan Hospital
  Toulouse, Occitanie, France Recruiting

Study contacts

• Study coordinator: Ana Raquel PINHEIRO BARBOSA
• Email: pinheirobarbosa.ar@chu-toulouse.fr
• Phone: (+33) 05.61.77.99.30

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.