Factors linked to low parathyroid function after thyroid removal
A Prospective Study to Assess Risk Factors for Hypoparathyroidism Following Thyroidectomy
We will see if magnesium levels and other patient or surgical factors are linked to developing low parathyroid function after removal of both thyroid lobes in adults.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Tartu University Hospital Academic / other |
| Locations | 2 sites (Tallinn and 1 other locations) |
| Trial ID | NCT07582562 on ClinicalTrials.gov |
What this trial studies
This is an observational study in Estonia collecting clinical data before and after thyroid surgery to determine how often post-thyroidectomy hypoparathyroidism occurs and which factors increase its risk. Participants complete a questionnaire and researchers record comorbidities, pre- and postoperative laboratory tests (including magnesium) and surgery-related details. No experimental treatments are given; the study analyzes routine clinical and lab data to identify associations. Findings will focus on the incidence in the local population and whether magnesium levels contribute to risk.
Who should consider this trial
Good fit: Adults (18+) undergoing surgery on both thyroid lobes who can give informed consent and are treated at the participating hospitals are the intended participants.
Not a fit: People having only a unilateral lobectomy or those having simultaneous parathyroid surgery for known parathyroid disease are excluded and likely will not benefit from this study's findings.
Why it matters
Potential benefit: If successful, identifying modifiable risk factors such as magnesium abnormalities could help prevent or better manage low parathyroid function after thyroid surgery.
How similar studies have performed: Previous observational work has identified surgical extent and inadvertent parathyroid damage as common risk factors, while the specific role of magnesium has been less consistently reported and remains under study.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients over the age of 18 undergoing surgery involving both lobes of the thyroid gland (thyroidectomy, "near-total" thyroidectomy, subtotal thyroidectomy, and "completed" thyroidectomy) * patients who are capable of giving informed consent Exclusion Criteria: * patients undergoing unilateral thyroid lobectomy only * patients with concomitant hyperparathyroidism undergoing simultaneous thyroidectomy and parathyroidectomy for a parathyroid adenoma
Where this trial is running
Tallinn and 1 other locations
- East Tallinn Central Hospital — Tallinn, Estonia (Recruiting)
- Tartu University Hospital — Tartu, Estonia (Recruiting)
Study contacts
- Study coordinator: Hanna Hollman, MD
- Email: hanna.hollman@ut.ee
- Phone: +37259037517
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.