Factors linked to low parathyroid function after thyroid removal
Official title: A Prospective Study to Assess Risk Factors for Hypoparathyroidism Following Thyroidectomy
Run by Tartu University Hospital · NCT07582562 · Data updated 2026-11-12
We will see if magnesium levels and other patient or surgical factors are linked to developing low parathyroid function after removal of both thyroid lobes in adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Tartu University Hospital Academic / other |
| Locations | 2 sites (Tallinn and 1 other locations) |
| Status | Recruiting |
| Started | October 13, 2025 |
| Main results expected | August 2027 |
| Study ends | December 2028 |
| Registry record updated | May 13, 2026 |
| Trial ID | NCT07582562 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) undergoing surgery on both thyroid lobes who can give informed consent and are treated at the participating hospitals are the intended participants.
✕Probably not a fit
People having only a unilateral lobectomy or those having simultaneous parathyroid surgery for known parathyroid disease are excluded and likely will not benefit from this study's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study in Estonia collecting clinical data before and after thyroid surgery to determine how often post-thyroidectomy hypoparathyroidism occurs and which factors increase its risk. Participants complete a questionnaire and researchers record comorbidities, pre- and postoperative laboratory tests (including magnesium) and surgery-related details. No experimental treatments are given; the study analyzes routine clinical and lab data to identify associations. Findings will focus on the incidence in the local population and whether magnesium levels contribute to risk.
Why it matters
Potential benefit: If successful, identifying modifiable risk factors such as magnesium abnormalities could help prevent or better manage low parathyroid function after thyroid surgery.
How similar studies have gone: Previous observational work has identified surgical extent and inadvertent parathyroid damage as common risk factors, while the specific role of magnesium has been less consistently reported and remains under study.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients over the age of 18 undergoing surgery involving both lobes of the thyroid gland (thyroidectomy, "near-total" thyroidectomy, subtotal thyroidectomy, and "completed" thyroidectomy) * patients who are capable of giving informed consent Exclusion Criteria: * patients undergoing unilateral thyroid lobectomy only * patients with concomitant hyperparathyroidism undergoing simultaneous thyroidectomy and parathyroidectomy for a parathyroid adenoma
Where it's running
-
East Tallinn Central Hospital
Tallinn, Estonia Recruiting -
Tartu University Hospital
Tartu, Estonia Recruiting
Study contacts
- Study coordinator: Hanna Hollman, MD
- Email: hanna.hollman@ut.ee
- Phone: +37259037517
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.