Eye imaging to understand childhood myopia
Official title: Modélisation de l'œil Myope Infantile Par IRM et OCT
Run by Essilor International · NCT07335146 · Data updated 2026-11-12
This project uses detailed eye imaging (optical measurements and MRI) to see if differences in eye anatomy explain why some children with nearsightedness respond differently to treatments.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Years to 12 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Essilor International Industry-sponsored |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | February 18, 2026 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | September 16, 2026 |
| Trial ID | NCT07335146 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children with a cycloplegic spherical equivalent between -6.5 D and +2.0 D who have social security coverage and parental consent are ideal candidates.
✕Probably not a fit
Children with neurological deficits, other progressive eye diseases, prior intraocular implants (aphakia/pseudophakia), ocular motility disorders (strabismus or nystagmus), or any contraindication to MRI are unlikely to be eligible or benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study collects ophthalmic geometric and wavefront measurements alongside MRI scans to map eye anatomy in children with myopia or mild hyperopia. Participants will undergo noninvasive optical measurements and an MRI to capture internal eye structures and optical aberrations. By comparing anatomical features with known patterns of myopia progression and treatment response, researchers aim to identify anatomical markers that could guide personalized myopia control. The study is sponsored by Essilor International and conducted at Hôpital Fondation Adolphe de Rothschild in Paris.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor myopia treatments to a child’s eye anatomy, improving control of progression and reducing long-term vision risks.
How similar studies have gone: Prior research has linked axial length and corneal/optical metrics to myopia progression, but combining MRI with detailed wavefront and geometric measures to personalize treatment response remains relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Spherical equivalent under cycloplegia greater -9.75 D and less than 2 D * Beneficiary of social security * Written consent from both holders of parental authority (or from one in case of exclusive parental authority) Exclusion Criteria: * Declared neurological deficit, including history of epileptic pathology or sensory-motor coordination disorders, vestibular or cerebellar pathology (for example, balance disorders) * Current or progressive pathology of the eyes or their appendages that may affect vision, other than myopia (examples: glaucoma, retinitis pigmentosa…) * Declared aphakia or pseudophakia (intraocular implant) * Ocular motility problem such as strabismus or nystagmus * Contraindication to MRI (claustrophobia, implanted devices such as pacemaker, etc.) * Wearing fixed orthodontic appliances that affect the quality of orbital MRI scans
Where it's running
-
Hôpital Fondation Adolphe de Rothschild
Paris, France Recruiting
Study contacts
- Study coordinator: Julien Savatosky, Doctor
- Email: jsavatovsky@for.paris
- Phone: 00331 48 03 69 30
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.