Eye imaging to understand childhood myopia
Modélisation de l'œil Myope Infantile Par IRM et OCT
This project uses detailed eye imaging (optical measurements and MRI) to see if differences in eye anatomy explain why some children with nearsightedness respond differently to treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 6 Years to 12 Years |
| Sex | All |
| Sponsor | Essilor International Industry-sponsored |
| Locations | 1 site (Paris) |
| Trial ID | NCT07335146 on ClinicalTrials.gov |
What this trial studies
The study collects ophthalmic geometric and wavefront measurements alongside MRI scans to map eye anatomy in children with myopia or mild hyperopia. Participants will undergo noninvasive optical measurements and an MRI to capture internal eye structures and optical aberrations. By comparing anatomical features with known patterns of myopia progression and treatment response, researchers aim to identify anatomical markers that could guide personalized myopia control. The study is sponsored by Essilor International and conducted at Hôpital Fondation Adolphe de Rothschild in Paris.
Who should consider this trial
Good fit: Children with a cycloplegic spherical equivalent between -6.5 D and +2.0 D who have social security coverage and parental consent are ideal candidates.
Not a fit: Children with neurological deficits, other progressive eye diseases, prior intraocular implants (aphakia/pseudophakia), ocular motility disorders (strabismus or nystagmus), or any contraindication to MRI are unlikely to be eligible or benefit from this protocol.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor myopia treatments to a child’s eye anatomy, improving control of progression and reducing long-term vision risks.
How similar studies have performed: Prior research has linked axial length and corneal/optical metrics to myopia progression, but combining MRI with detailed wavefront and geometric measures to personalize treatment response remains relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Spherical equivalent under cycloplegia greater -6.5 D and less than 2 D * Beneficiary of social security * Written consent from both holders of parental authority (or from one in case of exclusive parental authority) Exclusion Criteria: * Declared neurological deficit, including history of epileptic pathology or sensory-motor coordination disorders, vestibular or cerebellar pathology (for example, balance disorders) * Current or progressive pathology of the eyes or their appendages that may affect vision, other than myopia (examples: glaucoma, retinitis pigmentosa…) * Declared aphakia or pseudophakia (intraocular implant) * Ocular motility problem such as strabismus or nystagmus * Contraindication to MRI (claustrophobia, implanted devices such as pacemaker, etc.)
Where this trial is running
Paris
- Hôpital Fondation Adolphe de Rothschild — Paris, France (Recruiting)
Study contacts
- Study coordinator: Julien Savatosky, Doctor
- Email: jsavatovsky@for.paris
- Phone: 00331 48 03 69 30
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.