Exploring the tiny world inside the aortic valve during surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This non-randomized study collects blood and valve tissue during cardiac surgery to study the valve-associated microbiota and its possible link to outcomes after valve procedures. Researchers will sequence DNA from blood, use valve tissue from explanted valves, and track serious post-operative complications. The goal is to understand whether residual or introduced microbiota relate to valve degeneration, thrombosis, or other adverse events. The study is observational in nature with no experimental treatment given to patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female patient.
* Present an indication for cardiac surgery that requires explantation of the aortic valve.
* Be able to receive information about the study process and understand the study participation information form.
* State their non-opposition to participating in the study.

Exclusion Criteria:

* Patients infected with HIV
* Age under 18
* Under court supervision, guardianship, or curatorship
* Patients with a history of infective endocarditis.

Where it's running

• Rangueil Hospital
  Toulouse, France, France Recruiting

Study contacts

• Study coordinator: Bertrand MARCHEIX, MD
• Email: marcheix.b@chu-toulouse.fr
• Phone: 5 61 32 37 18

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.