Exploring the link between gut bacteria and spondyloarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This case-control study investigates the role of the bacterium Ruminococcus gnavus in the development of spondyloarthritis by comparing patients with the condition to healthy controls. It involves intestinal biopsies and fecal sampling to assess the abundance of R. gnavus and its interactions with intestinal mucus and epithelial cells. The study also aims to correlate gene expression in intestinal mucus with variations in microbiota and to demonstrate immune response perturbations caused by dysbiosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients with SPA:

* Patients ⩾ 18 years;
* Diagnosed as spondyloarthritis (SpA) according ASAS classification;
* Affiliated to a social security scheme;
* Have signed the written informed consent form.

Control subjects:

* Subjects ⩾ 18 years;
* Subjects free of SPA and planned for a digestive endoscopy for another indication such as to explore the risk of colorectal cancer in family member;
* Affiliated to a social security scheme;
* Have signed the written informed consent form.

Exclusion Criteria:

* Subjects unable to understand the proposed study and/or sign a informed consent form;
* Pregnant women or breast feeding women;
* Subjects under guardianship or curatorship;
* Have taken antibiotic 1 month prior to inclusion;
* Presenting acute or chronic severe pathology may likely to interfere with the interpret of outcome;
* Refusal of subjects to participate to the study;
* Foreign patients under french AME scheme.

Where it's running

• Service de Rhumatologie, Hôpital Ambroise Paré, APHP
  Boulogne-Billancourt, France Recruiting

Study contacts

• Principal investigator: Maxime BREBAN, MD, PhD — Service de Rhumatologie, Hôpital Ambroise Paré, APHP
• Study coordinator: Maxime BREBAN, MD, PhD
• Email: maxime.breban@aphp.fr
• Phone: +33 1 49 09 56 72

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• Gut bacteria test to predict response to biologic treatment in spondyloarthritis

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.