Exploring the link between gut bacteria and antibiotic resistance
Longitudinal Changes in Intestinal Microbiota and Its Association With Acquisition of Antimicrobial Resistance in a Cohort of Stroke Patients
This study looks at how gut bacteria might affect the risk of antibiotic resistance in patients who have had a stroke.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Locations | 1 site (Sha Tin) |
| Trial ID | NCT03794453 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between intestinal microbiota and antimicrobial resistance, particularly in patients who have experienced a stroke. It aims to understand how gut bacteria may influence the risk of acquiring multi-drug resistant organisms, which are a significant public health threat. By examining patients within two days of hospital admission for acute ischemic or hemorrhagic stroke, the study seeks to gather data that could inform strategies to combat antimicrobial resistance. The research highlights the urgent need to address the growing issue of drug-resistant infections.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have radiological evidence of acute ischemic or hemorrhagic stroke and are admitted to the hospital within two days.
Not a fit: Patients who have used antibiotics within four weeks prior to screening or have underlying gastrointestinal diseases will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new strategies for reducing the spread of antimicrobial resistance, ultimately improving patient outcomes.
How similar studies have performed: While the study addresses a critical area of antimicrobial resistance, similar studies exploring the role of intestinal microbiota in drug resistance have shown promise, indicating potential for impactful findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years or above, and * Radiological evidence of acute ischaemic or hemorrhagic stroke * Within two days of hospital admission Exclusion Criteria: * Use of antibiotics within 4 weeks prior to the time of screening * Underlying gastrointestinal diseases, including gastrointestinal malignancy, inflammatory bowel disease, resection of small or large bowel * Pregnancy
Where this trial is running
Sha Tin
- Prince of Wales Hospital — Sha Tin, Hong Kong (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.