Clinical trial No longer in our active list Observational Ages 18 and up

Exploring the link between gut bacteria and antibiotic resistance

Official title: Longitudinal Changes in Intestinal Microbiota and Its Association With Acquisition of Antimicrobial Resistance in a Cohort of Stroke Patients

Run by Chinese University of Hong Kong · NCT03794453 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study looks at how gut bacteria might affect the risk of antibiotic resistance in patients who have had a stroke.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment200 (estimated)
SponsorChinese University of Hong Kong
Academic / other
Locations1 site (Sha Tin)
Trial IDNCT03794453 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who have radiological evidence of acute ischemic or hemorrhagic stroke and are admitted to the hospital within two days.

Probably not a fit

Patients who have used antibiotics within four weeks prior to screening or have underlying gastrointestinal diseases will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between intestinal microbiota and antimicrobial resistance, particularly in patients who have experienced a stroke. It aims to understand how gut bacteria may influence the risk of acquiring multi-drug resistant organisms, which are a significant public health threat. By examining patients within two days of hospital admission for acute ischemic or hemorrhagic stroke, the study seeks to gather data that could inform strategies to combat antimicrobial resistance. The research highlights the urgent need to address the growing issue of drug-resistant infections.

Why it matters

Potential benefit: If successful, this study could lead to new strategies for reducing the spread of antimicrobial resistance, ultimately improving patient outcomes.

How similar studies have gone: While the study addresses a critical area of antimicrobial resistance, similar studies exploring the role of intestinal microbiota in drug resistance have shown promise, indicating potential for impactful findings.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults aged 18 years or above, and
* Radiological evidence of acute ischaemic or hemorrhagic stroke
* Within two days of hospital admission

Exclusion Criteria:

* Use of antibiotics within 4 weeks prior to the time of screening
* Underlying gastrointestinal diseases, including gastrointestinal malignancy, inflammatory bowel disease, resection of small or large bowel
* Pregnancy

Where it's running

  • Prince of Wales Hospital
    Sha Tin, Hong Kong
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.