Exploring the effects of Tuina on Tourette's Syndrome in children
Peripheral Mechanisms of Humoral Immune Effector-mediated Tourette's Syndrome and the Role of Tuina Intervention
This study is testing whether a traditional Chinese therapy called Tuina can help children with Tourette's Syndrome feel better and improve their symptoms.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 4 Years to 18 Years |
| Sex | All |
| Sponsor | The First Affiliated Hospital of Zhejiang Chinese Medical University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT06379373 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of Tuina, a traditional Chinese spinal manipulation technique, on children diagnosed with Tourette's Syndrome (TS). It aims to evaluate clinical efficacy using the Yale Tourette's Syndrome Global Severity Scale and assess changes in inflammatory markers and humoral immune responses before and after the intervention. The study will analyze serum levels of various cytokines and immunoglobulins to understand the underlying immune mechanisms associated with TS. By comparing these levels in children with TS to healthy controls, the research seeks to clarify the role of immune factors in the condition.
Who should consider this trial
Good fit: Ideal candidates for this study are children diagnosed with Tourette's Syndrome who have not recently taken medications affecting the study's outcomes.
Not a fit: Patients with severe tics, other extrapyramidal diseases, or significant comorbid conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-pharmacological treatment option for managing Tourette's Syndrome in children.
How similar studies have performed: While previous studies have shown positive effects of Tuina on TS, this specific approach focusing on immune mechanisms is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Outpatients who meet the diagnostic criteria for TS； * Haven't taken any drugs that affect the efficacy evaluation, such as antipsychotic drugs or traditional Chinese medicines with similar effects, or have received treatment but have passed the drug washout period for more than 1 month before enrollment； * The legal guardian and the subject themselves have been informed consent, and have signed the informed consent form, agreeing to participate in this trial, and have been reviewed and approved by the Ethics Committee of Zhejiang Provincial Hospital of Traditional Chinese Medicine. Exclusion Criteria: * Any chorenia, Wilson's disease, epileptic myoclonus, drug-induced extrapyramidal symptoms and other extrapyramidal diseases; * A history of severe tics; * Any primary diseases such as cardiovascular, hepatic, renal and hematopoietic systems; * Allergic or allergic to the drug in this test; * Current taking other drugs or accept other treatments at the same time affect the evaluation of efficacy
Where this trial is running
Hangzhou, Zhejiang
- First Affiliated Hospital of Zhejiang Chinese Medical University — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Principal investigator: xiaojuan Li — The First Affiliated Hospital of Zhejiang Chinese Medical University
- Study coordinator: cun wen
- Email: wencunyatb@163.com
- Phone: +86-571-13857135576
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.