Exploring the connection between stroke, delirium, and long-term cognitive issues
DEliriuM in STroke: the Link Between Stroke, Delirium and Long-term Cognitive Impairment
Universitair Ziekenhuis Brussel · NCT06650436
This study is trying to see if having delirium after a stroke can lead to long-term thinking problems, regardless of other brain issues or past cognitive health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitair Ziekenhuis Brussel (other) |
| Locations | 1 site (Brussels) |
| Trial ID | NCT06650436 on ClinicalTrials.gov |
What this trial studies
This observational study aims to determine if post-stroke delirium (PSD) is a risk factor for post-stroke cognitive impairment (PSCI), independent of brain frailty and pre-existing cognitive function. It will document patient characteristics, stroke severity, and assess delirium during hospitalization using the 4 'A's Test. Additionally, the study will investigate the impact of infarct location and brain network disintegration on the development of both PSD and PSCI. Clinical assessments will be repeated at 3 and 12 months to monitor changes in cognitive function.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have experienced their first-ever ischemic stroke within the last 72 hours and can participate in cognitive assessments.
Not a fit: Patients with a history of epilepsy, pre-existing brain lesions, or severe cognitive impairments that hinder assessment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cognitive impairment following a stroke.
How similar studies have performed: While the specific link between PSD and PSCI is being explored, similar studies have shown promising results in understanding cognitive outcomes post-stroke.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years or older, * clinical diagnosis of first-ever ischemic stroke (onset \<72h at time of inclusion), * admitted at stroke unit of UZ Brussel, * ability to participate in cognitive assessments, * fluency in Dutch or French, * ability to undergo an EEG during the first 24 hours after onset of stroke symptoms, * ability to undergo MRI of the brain. Exclusion Criteria: * epilepsy history, * pre-existing, space occupying brain lesion (except small meningeoma), * pregnancy or wish to become pregnant, * severe language impairment or dementia impeding cognitive assessment, life expectancy of less than 1 year.
Where this trial is running
Brussels
- Universitair Ziekenhuis Brussel — Brussels, Belgium (RECRUITING)
Study contacts
- Study coordinator: Fenne Vandervorst, MD
- Email: fenne.vandervorst@uzbrussel.be
- Phone: 024776801
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Ischemic Stroke, Delirium, Cognitive Impairment, Post stroke delirium, Post-stroke cognitive impairment, EEG