Exploring Red Blood Cell Disorders

Pathophysiological Explorations of Red Blood Cells

This study is trying to learn more about red blood cell disorders by collecting samples from people with these conditions or their family members to help create better treatments.

Quick facts

• Study type: Observational
• Enrollment: 3750 (estimated)
• Sex: All
• Sponsor: Imagine Institute (Academic / other)
• Locations: 25 sites (Cotonou and 24 other locations)
• Trial ID: NCT03541525 on ClinicalTrials.gov

What this trial studies

This observational program, GR-Ex, is designed to enhance understanding of red blood cell physiology, erythropoiesis, and iron metabolism. It involves biological sampling from participants who have red blood cell disorders or a family history of such conditions. The initiative aims to develop innovative therapeutic protocols that could improve treatment outcomes for these disorders. The study is supported by the French Ministry of Higher Education and Research as part of a Laboratory of Excellence program.

Who should consider this trial

Good fit: Ideal candidates include individuals affected by red blood cell disorders or those with a family history of these conditions.

Not a fit: Patients who are deprived of freedom will not benefit from this study.

Why it matters

Potential benefit: If successful, this program could lead to new therapeutic approaches for patients with red blood cell disorders.

How similar studies have performed: Other studies focusing on red blood cell disorders have shown promise in understanding and treating these conditions, indicating that this approach is building on existing knowledge.

Eligibility criteria

Inclusion Criteria:

* To be affected or have a family history of disease bound to the red blood cell,
* For adult subjects, have signed an informed consent form,
* For minor or major under legal safeguard subjects, the form must be signed by both parents (for minors) or by the legal representative,
* Be affiliated to health insurance.

Exclusion Criteria:

* Being deprived of freedom

Where this trial is running

Cotonou and 24 other locations

• CHU Hôpital de la Mère et de l'enfant Lagune — Cotonou, Benin (Not_yet_recruiting)
• CHU Amiens-Picardie — Amiens, France (Recruiting)
• Hôpital Privé d'Antony — Antony, France (Recruiting)
• Hôpital Avicenne — Bobigny, France (Recruiting)
• Hôpital Pellegrin — Bordeaux, France (Recruiting)
• Hôpital Beaujon — Clichy, France (Recruiting)
• Hôpital Louis Mourier — Colombes, France (Recruiting)
• Hopital Henri Mondor — Créteil, France (Recruiting)
• CHU Kremlin Bicetre — Le Kremlin-Bicêtre, France (Recruiting)
• Hopital de la conception — Marseille, France (Recruiting)
• Hôpital d'Enfants de la TIMONE — Marseille, France (Recruiting)
• Hôpital Saint Eloi — Montpellier, France (Recruiting)
• CHU de Niort — Niort, France (Recruiting)
• Groupe Hospitalier Diaconesses Croix Saint Simon — Paris, France (Recruiting)
• Hopital Necker - Enfants malades — Paris, France (Recruiting)
• Hôpital Armand Trousseau — Paris, France (Recruiting)
• Hôpital Cochin — Paris, France (Recruiting)
• Hôpital Européen Georges-Pompidou — Paris, France (Recruiting)
• Hôpital Robert Debré — Paris, France (Not_yet_recruiting)
• Hôpital Saint Louis — Paris, France (Recruiting)
• Hôpital Saint-Antoine — Paris, France (Recruiting)
• Institut Pasteur — Paris, France (Recruiting)
• CHU de Rouen — Rouen, France (Recruiting)
• Hôpital national d'instruction des armées Bégin — Saint-Mandé, France (Recruiting)
• CHU de la Guadeloupe — Pointe-à-Pitre, Guadeloupe (Not_yet_recruiting)

Study contacts

• Study coordinator: Sandra Manceau, PhD

Conditions Red Blood Cell Disorder