Exploring Muscle Structure in Children with Cerebral Palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the microscopic muscle structure in children diagnosed with cerebral palsy (CP). It focuses on understanding how muscle morphology, particularly in the biceps brachii and gastrocnemius muscles, changes over time in response to standard care practices, including botulinum toxin injections and physical training. The study aims to assess the expression of specific myosin heavy chains as indicators of muscle growth and adaptation. By examining these changes longitudinally, the research seeks to provide insights into the effectiveness of current treatment approaches for managing muscle spasticity and contraction in CP.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Cerebral Palsy, Aquired Brain Injury

Exclusion Criteria:

* Progressive neural disease

Where it's running

• Karolinska University Hospital
  Stockholm, Sweden Recruiting

Study contacts

• Principal investigator: Eva M Pontén, MD PhD — Karolinska Institutet
• Study coordinator: Eva M Pontén, MD PhD
• Email: eva.ponten@ki.se
• Phone: +46706303052

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Examining muscle changes in children with cerebral palsy during surgery

  This study looks at muscle changes in children with cerebral palsy during surgery to see how their muscles differ from those of typically developing kids, hoping to find better ways to help them move more easily.

  Recruiting Region Stockholm · Stockholm · NCT05506228

• Sensory Integration Therapy vs Conventional Physical Therapy in Children With Mixed Cerebral Palsy

  This study tests whether Sensory Integration Therapy helps improve gross motor function more than standard physical therapy in children aged 4–10 with mixed cerebral palsy.

  Recruiting Riphah International University · Peshawar, Kpk · NCT07921069

• Turkish version of ABILHAND-Kids Young CP: translation, adaptation, and reliability

  A Turkish version of the ABILHAND-Kids Young CP questionnaire is being created and tested to see if it reliably measures manual ability in 2-to-7-year-olds with cerebral palsy, based on parent reports.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Istanbul · NCT07894926

• Multisite upper limb surgery in children with unilateral cerebral palsy

  This study looks at whether individualized multisite upper limb surgery helps improve hand function in kids with hemiplegic cerebral palsy, using each child as their own control before and after surgery.

  Recruiting Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française · Lyon · NCT07891078

• Spinal Stimulation During Walking to See If Spasticity Lessens in Cerebral Palsy

  This study tests whether walking with non-invasive spinal stimulation reduces leg muscle tightness and improves walking in children and young adults with cerebral palsy.

  Recruiting University of Washington · Seattle, Washington · NCT07826494

• Combined leg nerve blocks for kids with cerebral palsy after surgery

  This study tests whether adding two nerve blocks to standard anesthesia helps control pain in children with cerebral palsy after lower limb surgery.

  Recruiting Diskapi Yildirim Beyazit Education and Research Hospital · Ankara · NCT07801365

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.