Exploring Muscle Structure in Children with Cerebral Palsy
The Muscle in Children Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure in Gastrocnemius and Biceps Brachii During Two Years of Care as Usual, Including Training With Botulinum Toxin Injections as Adjuvant Therapy.
This study looks at how the muscles of children with cerebral palsy change over time to see if standard treatments like therapy and injections help improve muscle growth and function.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 2 Years to 18 Years |
| Sex | All |
| Sponsor | Region Stockholm Government |
| Locations | 1 site (Stockholm) |
| Trial ID | NCT05497609 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the microscopic muscle structure in children diagnosed with cerebral palsy (CP). It focuses on understanding how muscle morphology, particularly in the biceps brachii and gastrocnemius muscles, changes over time in response to standard care practices, including botulinum toxin injections and physical training. The study aims to assess the expression of specific myosin heavy chains as indicators of muscle growth and adaptation. By examining these changes longitudinally, the research seeks to provide insights into the effectiveness of current treatment approaches for managing muscle spasticity and contraction in CP.
Who should consider this trial
Good fit: Ideal candidates for this study are children diagnosed with cerebral palsy or acquired brain injury.
Not a fit: Patients with progressive neural diseases will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of muscle adaptations in children with cerebral palsy, potentially leading to improved treatment strategies.
How similar studies have performed: While there have been studies on muscle adaptations in cerebral palsy, this specific longitudinal approach focusing on microscopic muscle structure is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cerebral Palsy, Aquired Brain Injury Exclusion Criteria: * Progressive neural disease
Where this trial is running
Stockholm
- Karolinska University Hospital — Stockholm, Sweden (Recruiting)
Study contacts
- Principal investigator: Eva M Pontén, MD PhD — Karolinska Institutet
- Study coordinator: Eva M Pontén, MD PhD
- Email: eva.ponten@ki.se
- Phone: +46706303052
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.