Examining muscle changes in children with cerebral palsy during surgery
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery of Children With Cerebral Palsy and Typically Developed Children (Control).
Region Stockholm · NCT05506228
This study looks at muscle changes in children with cerebral palsy during surgery to see how their muscles differ from those of typically developing kids, hoping to find better ways to help them move more easily.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 2 Years to 18 Years |
| Sex | All |
| Sponsor | Region Stockholm (other gov) |
| Locations | 1 site (Stockholm) |
| Trial ID | NCT05506228 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the muscle changes associated with cerebral palsy (CP) and acquired brain injury (ABI) by analyzing muscle biopsies taken during necessary orthopedic surgeries. The study aims to compare these samples with those from typically developed children undergoing similar procedures to understand the underlying mechanisms of muscle stiffness and contractures. By examining inflammatory markers and signaling pathways related to muscle and tendon health, the research seeks to uncover potential treatment strategies to improve muscle and joint function in affected children.
Who should consider this trial
Good fit: Ideal candidates include children and adolescents with cerebral palsy or acquired brain injury undergoing orthopedic surgery, as well as typically developed children for comparison.
Not a fit: Patients with progressive neurological diseases or other metabolic or muscle diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies that protect muscle and joint health in children with cerebral palsy.
How similar studies have performed: While the specific approach of this study is novel, similar studies have shown promise in understanding muscle pathology in related conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children and adolescents undergoing clinically needed orthopaedic surgery * with Cerebral Palsy or Acquired Brain Injury * Typically developed children and adolescents (control) Exclusion Criteria: * for CP/ABI: Progressive neurological disease, other metabolic or muscle disease * for TD (Control): Cerebral Palsy, Acquired Brain injury, other metabolic or muscle diseases
Where this trial is running
Stockholm
- Karolinska University Hospital — Stockholm, Sweden (RECRUITING)
Study contacts
- Principal investigator: Eva M Pontén, MD PhD — Karolinska Institutet
- Study coordinator: Eva M Pontén, MD PhD
- Email: eva.ponten@ki.se
- Phone: +46706303052
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cerebral Palsy, Muscle, Muscle Contracture, Muscle Spasticity, Upper Limb, Lower Limb, Muscle Biopsy, Plasma