Examining muscle changes in children with cerebral palsy during surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the muscle changes associated with cerebral palsy (CP) and acquired brain injury (ABI) by analyzing muscle biopsies taken during necessary orthopedic surgeries. The study aims to compare these samples with those from typically developed children undergoing similar procedures to understand the underlying mechanisms of muscle stiffness and contractures. By examining inflammatory markers and signaling pathways related to muscle and tendon health, the research seeks to uncover potential treatment strategies to improve muscle and joint function in affected children.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children and adolescents undergoing clinically needed orthopaedic surgery
* with Cerebral Palsy or Acquired Brain Injury
* Typically developed children and adolescents (control)

Exclusion Criteria:

* for CP/ABI: Progressive neurological disease, other metabolic or muscle disease
* for TD (Control): Cerebral Palsy, Acquired Brain injury, other metabolic or muscle diseases

Where it's running

• Karolinska University Hospital
  Stockholm, Sweden Recruiting

Study contacts

• Principal investigator: Eva M Pontén, MD PhD — Karolinska Institutet
• Study coordinator: Eva M Pontén, MD PhD
• Email: eva.ponten@ki.se
• Phone: +46706303052

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.