Exploring kidney transplant tolerance using blood samples
Official title: Non-interventional Single-center Study of the Contribution of DP8α Regulatory T Cells Induced by a Gut Microbiota Bacterium to Kidney Transplant Tolerance.
Run by Nantes University Hospital · NCT06271343 · Data updated 2026-11-12
This study looks at blood samples from kidney transplant patients to see if certain immune cells can help prevent the body from rejecting the new kidney.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 1 site (Nantes, Loire-Atlantique) |
| Status | Recruiting |
| Started | May 14, 2024 |
| Main results expected | August 22, 2027 |
| Study ends | August 22, 2027 |
| Registry record updated | May 5, 2026 |
| Trial ID | NCT06271343 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adult patients undergoing their first or second kidney transplant from a related living donor with a BMI under 35.
✕Probably not a fit
Patients with ABO incompatibility or a BMI over 35 may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate kidney transplant tolerance by analyzing peripheral blood mononuclear cells (PBMC) from adult donor-recipient pairs treated at Nantes University Hospital. The study will focus on the role of DP8α regulatory T cells expressing CD73, which are hypothesized to be involved in preventing transplant rejection. Blood samples will be collected during routine clinical visits to assess the frequency of these Tregs and their potential donor-specific characteristics. The goal is to understand how these immune cells contribute to tolerance in kidney transplants.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for preventing kidney transplant rejection, enhancing patient outcomes.
How similar studies have gone: While the specific approach of this study is novel, similar studies exploring transplant tolerance have shown promising results in the past.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult donor-recipient pair. * First or second kidney transplant from a related ABO-compatible living donor. * BMI \< 35 for recipients. * Adult patients. * Patients weighing over 50 kgs. Exclusion Criteria: * Donor/recipient ABO incompatibility * BMI \> 35 for recipients
Where it's running
-
Nantes University Hospital
Nantes, Loire-Atlantique, France Recruiting
Study contacts
- Study coordinator: Christophe MASSET, PH
- Email: christophe.masset@chu-nantes.fr
- Phone: 33 2 76 64 39 61
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.