Clinical trial Recruiting at 1 site Interventional Ages 18 to 45

Exploring how motivation affects learning through a treasure task

Official title: The Influence of Mesolimbic-hippocampal Interactions on Episodic Memory During Active Information Seeking

Run by Temple University · NCT06257433 · Data updated 2026-11-12

This study tests how motivation impacts learning by having participants play a treasure hunt game while their brain activity is monitored.

Quick facts

Study typeInterventional
Ages18 Years to 45 Years
SexAll
Enrollment80 (estimated)
SponsorTemple University
Academic / other
Locations1 site (Philadelphia, Pennsylvania)
StatusRecruiting
StartedOctober 24, 2023
Main results expectedAugust 1, 2026
Study endsAugust 1, 2026
Registry record updatedSeptember 5, 2025
Trial IDNCT06257433 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are healthy adults aged 18 and older with normal or corrected vision.

Probably not a fit

Patients with a history of head injury, central nervous system illnesses, or those on medications affecting alertness may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between motivation and learning by having participants engage in a treasure task during neuroimaging. Participants will select from three keys to determine which feature unlocks a treasure chest, revealing unique images. The task is designed to manipulate goal-oriented exploration and uncertainty resolution by changing the target feature of the key after successful attempts. Participants will complete multiple runs of hypothesis testing and control tasks to assess their learning and decision-making processes.

Why it matters

Potential benefit: If successful, this study could enhance our understanding of motivation's role in learning, potentially leading to improved strategies for educational and therapeutic interventions.

How similar studies have gone: While the specific approach of this study is novel, similar studies exploring motivation and learning have shown promising results.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 20/40 far acuity (either corrected or uncorrected)
* In good medical health

Exclusion Criteria:

* History of head injury
* History of illness with Central Nervous Systems implications
* On Medications that Affect blood flow response and alertness
* Consumption of smoking and/or coffee 30 minutes prior to laboratory testing
* Placement of a device contraindicated for magnetic resonance imaging including cardia pacemaker, aneurysm clip, cochlear implants, pregnancy, intra-uterine device, shrapnel, metal fragments in the eyes, neurostimulators
* Weight \> 250lbs
* Claustrophobia

Where it's running

  • Temple University
    Philadelphia, Pennsylvania, United States
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.