Exploring how brain stimulation affects perception and cognition
Official title: Investigating the Plasticity of Human Predictive Coding Through Neuromodulation: an Interventional, Monocentric, Randomized, Single-blinded Study on Healthy Adult Volunteers
Run by Università Vita-Salute San Raffaele · NCT06374433 · Data updated 2026-11-12
This study is testing how different types of brain stimulation can change the way healthy adults think and perceive things.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 35 Years |
| Sex | All |
| Enrollment | 210 (estimated) |
| Sponsor | Università Vita-Salute San Raffaele Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | June 13, 2024 |
| Main results expected | April 30, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | June 14, 2024 |
| Trial ID | NCT06374433 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults aged 18-35 with normal or corrected vision.
✕Probably not a fit
Patients with neurological disorders or those on specific psychopharmacological treatments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of different transcranial electrical stimulation methods on the brain's predictive coding mechanisms in healthy adults. It employs a randomized, single-blinded design to assess how varying frequencies and stimulation networks influence cognitive processes. Participants aged 18-35 will be recruited from the general population and will undergo various stimulation protocols, including transcranial alternating current stimulation and transcranial random noise stimulation. The goal is to enhance understanding of brain plasticity and its implications for cognition.
Why it matters
Potential benefit: If successful, this research could lead to new non-invasive treatments for cognitive impairments.
How similar studies have gone: Other studies have shown promise in using neuromodulation techniques to influence cognitive functions, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Aged 18-35 years. * Normal or corrected to normal vision, as per anamnestic investigation. Exclusion Criteria: * Participants with a diagnosis of epilepsy (as per anamnestic investigation). * Participants with major neurological disorders (as per anamnestic investigation). * Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation). * Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).
Where it's running
-
Università Vita-Salute San Raffaele
Milan, Italy Recruiting
Study contacts
- Study coordinator: Luca Ronconi, PhD
- Email: ronconi.luca@unisr.it
- Phone: 0226434887
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.