Exploring how brain stimulation affects perception and cognition
Investigating the Plasticity of Human Predictive Coding Through Neuromodulation: an Interventional, Monocentric, Randomized, Single-blinded Study on Healthy Adult Volunteers
This study is testing how different types of brain stimulation can change the way healthy adults think and perceive things.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 210 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | Università Vita-Salute San Raffaele Academic / other |
| Locations | 1 site (Milan) |
| Trial ID | NCT06374433 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of different transcranial electrical stimulation methods on the brain's predictive coding mechanisms in healthy adults. It employs a randomized, single-blinded design to assess how varying frequencies and stimulation networks influence cognitive processes. Participants aged 18-35 will be recruited from the general population and will undergo various stimulation protocols, including transcranial alternating current stimulation and transcranial random noise stimulation. The goal is to enhance understanding of brain plasticity and its implications for cognition.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-35 with normal or corrected vision.
Not a fit: Patients with neurological disorders or those on specific psychopharmacological treatments may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to new non-invasive treatments for cognitive impairments.
How similar studies have performed: Other studies have shown promise in using neuromodulation techniques to influence cognitive functions, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Aged 18-35 years. * Normal or corrected to normal vision, as per anamnestic investigation. Exclusion Criteria: * Participants with a diagnosis of epilepsy (as per anamnestic investigation). * Participants with major neurological disorders (as per anamnestic investigation). * Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation). * Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).
Where this trial is running
Milan
- Università Vita-Salute San Raffaele — Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Luca Ronconi, PhD
- Email: ronconi.luca@unisr.it
- Phone: 0226434887
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.