Exploring genetic factors in gallbladder cancer treatment responses
Official title: Genetic Mutations and Response to Treatment in Gallbladder Cancer: A Hospital Based Cohort Study
Run by Banaras Hindu University · NCT05404347 · Data updated 2026-11-12
This study is trying to see how certain genetic changes in people with gallbladder cancer affect how well they respond to treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Banaras Hindu University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Varanasi, Uttar Pradesh) |
| Status | Recruiting |
| Started | January 1, 2018 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 13, 2024 |
| Trial ID | NCT05404347 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are treatment-naïve patients with histologically proven gallbladder carcinoma.
✕Probably not a fit
Patients without histological evidence of malignancy or those who are pregnant or lactating may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the genetic mutations associated with gallbladder cancer and their potential impact on treatment responses. By utilizing next-generation sequencing, the study aims to identify key oncogenes and tumor suppressor genes that may influence patient outcomes. The research focuses on treatment-naïve patients with histologically confirmed gallbladder carcinoma, aiming to bridge the gap between genetic profiling and personalized treatment strategies. The findings could provide insights into the molecular mechanisms driving gallbladder cancer and inform future therapeutic approaches.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment options for patients with gallbladder cancer based on their genetic profiles.
How similar studies have gone: While there have been promising clinical trials in other cancers utilizing genetic profiling, the application of these principles in gallbladder cancer remains largely unexplored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Treatment naïve patients with histologically proven carcinoma of the gallbladder. Exclusion Criteria: * No histological evidence of malignancy * Pregnant and lactating women
Where it's running
-
Banaras Hindu University
Varanasi, Uttar Pradesh, India Recruiting
Study contacts
- Principal investigator: Manoj Pandey, Ms, PhD — Banaras Hindu University
- Study coordinator: Manoj Pandey, MS, PhD
- Email: mpandey66@bhu.ac.in
- Phone: 2361014
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.