Exploring genetic factors in gallbladder cancer treatment responses
Genetic Mutations and Response to Treatment in Gallbladder Cancer: A Hospital Based Cohort Study
This study is trying to see how certain genetic changes in people with gallbladder cancer affect how well they respond to treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Banaras Hindu University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Varanasi, Uttar Pradesh) |
| Trial ID | NCT05404347 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the genetic mutations associated with gallbladder cancer and their potential impact on treatment responses. By utilizing next-generation sequencing, the study aims to identify key oncogenes and tumor suppressor genes that may influence patient outcomes. The research focuses on treatment-naïve patients with histologically confirmed gallbladder carcinoma, aiming to bridge the gap between genetic profiling and personalized treatment strategies. The findings could provide insights into the molecular mechanisms driving gallbladder cancer and inform future therapeutic approaches.
Who should consider this trial
Good fit: Ideal candidates for this study are treatment-naïve patients with histologically proven gallbladder carcinoma.
Not a fit: Patients without histological evidence of malignancy or those who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment options for patients with gallbladder cancer based on their genetic profiles.
How similar studies have performed: While there have been promising clinical trials in other cancers utilizing genetic profiling, the application of these principles in gallbladder cancer remains largely unexplored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Treatment naïve patients with histologically proven carcinoma of the gallbladder. Exclusion Criteria: * No histological evidence of malignancy * Pregnant and lactating women
Where this trial is running
Varanasi, Uttar Pradesh
- Banaras Hindu University — Varanasi, Uttar Pradesh, India (Recruiting)
Study contacts
- Principal investigator: Manoj Pandey, Ms, PhD — Banaras Hindu University
- Study coordinator: Manoj Pandey, MS, PhD
- Email: mpandey66@bhu.ac.in
- Phone: 2361014
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.