Identifying risk factors for gallbladder cancer and gallstone disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on gallbladder cancer (GBC) and gallstone disease, aiming to improve early detection and risk estimation for GBC. Researchers will analyze various epidemiological factors, including geographical, environmental, lifestyle, and genetic influences, to develop a multifactorial risk score. The study will also create a biorepository and an IT platform to facilitate the identification and validation of novel GBC biomarkers. By understanding the causal mechanisms linking lifestyle and GBC, the study seeks to enhance prevention strategies and guide clinical decisions regarding gallbladder removal.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Cohort A. Patients with gallbladder cancer or dysplasia, both before and after the start of their anticancer treatment.

   Cohort B. Patients with cholelithiasis before cholecystectomy (only patients scheduled for cholecystectomy will be recruited)
2. Diagnosis confirmed in accordance with standard protocols of the participating hospitals
3. Men and women aged 18 or over

Exclusion Criteria:

1. Any medical condition that present an unreasonable risk to the participant.
2. Any psychiatric condition that interferes with understanding informed consent.

Where it's running

• Hospital Papa Francisco
  Salta, Argentina Recruiting
• Sanatorio el Carmen
  Salta, Argentina Recruiting
• Hospital Pablo Soria
  San Salvador de Jujuy, Argentina Recruiting
• Complejo Hospitalario Viedma
  Cochabamba, Bolivia Recruiting
• Hospital del Norte
  Cochabamba, Bolivia Recruiting
• Hospital Obrero No. 2 (Caja Nacional del Seguro Social)
  Cochabamba, Bolivia Recruiting

Study contacts

• Principal investigator: Justo LORENZO BERMEJO, PhD — Heidelberg University Hospital (UKHD, Germany) and Centre Paul Strauss (CPS, France)
• Study coordinator: Dominique SCHERER, PhD
• Email: scherer@imbi.uni-heidelberg.de
• Phone: +49 6221 56 7303

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• CD160-Enhanced Autologous T Cells for Advanced Biliary Tract Cancer

  This trial tests a patient‑made T cell therapy (BTC-Ag-T) to see if it is safe and can help people with advanced biliary tract cancer who have exhausted standard treatments.

  Recruiting Phase 1 Shanghai Zhongshan Hospital · Shanghai · NCT07614061

• Ultrasound in bariatric care to prevent gallstone problems

  This study tests whether preoperative gallbladder ultrasound and related imaging help identify who might benefit from preventive Ursochol after bariatric surgery.

  Recruiting Esbjerg Hospital - University Hospital of Southern Denmark · Esbjerg · NCT07453186

• Comparing Trimedat 76.95 mg orally disintegrating tablets with Trimedat 100 mg tablets in healthy adults

  This will test if Trimedat 76.95 mg dissolving tablets work the same and are as safe as Trimedat 100 mg tablets when taken fasting by healthy adults.

  Recruiting Phase 1 Valenta Pharm JSC · Saint Petersburg · NCT07421011

• TENS to reduce anxiety, pain, and improve satisfaction after laparoscopic gallbladder removal

  This trial will try TENS (mild electrical stimulation through the skin) in adults having elective laparoscopic gallbladder removal to see if it lowers anxiety, reduces postoperative pain, and improves satisfaction.

  Recruiting Nigde Omer Halisdemir University · Niğde, Adana · NCT07307703

• Testing MDX2001 for advanced solid tumors

  This study is testing a new drug called MDX2001 to see if it can safely help people with advanced solid tumors like breast or colon cancer.

  Recruiting at 6 sites Phase 1/2 ModeX Therapeutics, An OPKO Health Company · Denver, Colorado and 5 other locations · NCT06239194

• Comparing two methods of pain management during laparoscopic gallbladder surgery

  This study is testing whether a new pain management method that combines two techniques can help people feel less pain after gallbladder surgery compared to just one technique.

  Recruiting Helsinki University Central Hospital · Espoo, Uusimaa · NCT06123117

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.