Exploring brain structure and gene expression in mental disorders
Psychiatric Multi-omics and Neuroimaging Project Database
This study looks at how brain structure and genes relate to schizophrenia and other mental disorders in young people to better understand these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1899 (estimated) |
| Ages | 13 Years to 35 Years |
| Sex | All |
| Sponsor | Second Xiangya Hospital of Central South University Academic / other |
| Locations | 1 site (Changsha, Hunan) |
| Trial ID | NCT06580860 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between brain structure, function, and gene expression in patients with schizophrenia and other mental disorders. Participants aged 13-35 will undergo baseline and follow-up assessments while adhering to their prescribed medications for one year. The goal is to identify biological markers and understand how gene-environment interactions affect brain networks, which could enhance the understanding of schizophrenia's neuropathological basis.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 13-35 with a diagnosis of schizophrenia or other specified mental disorders who have been ill for less than 24 months.
Not a fit: Patients with a family history of psychotic disorders or those with significant physical or neurological diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for schizophrenia and related mental disorders.
How similar studies have performed: While there have been studies exploring similar biological markers in mental disorders, this specific multi-omics approach combined with neuroimaging is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 13-35 years old(Patients with healthy siblings can be extended to 14-35 years of age) * Course of disease: \<24 months * Priority is given to patients who have never taken medicine or duration of drug use \< 2 weeks * No nuclear magnetic contraindications. Exclusion Criteria: * Family history of psychotic disorders, history of psychoactive substances abuse, alcohol dependence, or nicotine dependence * Have a major physical disease or infectious disease * History of coma and serious neurological disease 4.MRI contraindications.
Where this trial is running
Changsha, Hunan
- The Second Xiangya hospital of central south univerity — Changsha, Hunan, China (Recruiting)
Study contacts
- Study coordinator: Yunzhi Pan
- Email: panyunzhi@csu.edu.cn
- Phone: 15074818197
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.