Treatment options for brain arteriovenous malformations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to determine the best management strategies for patients with brain arteriovenous malformations (AVMs), whether they are ruptured or unruptured. It will evaluate the effectiveness of medical management versus interventional therapies, including neurosurgery, radiation therapy, and embolization, in reducing the risk of death or debilitating stroke over a 10-year period. The study also seeks to assess if pre-surgical embolization can enhance the safety and efficacy of subsequent treatments. By analyzing long-term outcomes, the study hopes to provide clearer guidance on managing AVMs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Any patient with a brain AVM

Exclusion Criteria:

* Hemorrhagic presentation with mass effect requiring surgical management. In these cases, if a residual AVM is found after the initial surgery, the patient could then be a candidate for TOBAS.

Where it's running

• Mayo Clinic in Jacksonville FL
  Jacksonville, Florida, United States Recruiting
• Boston Medical Center
  Boston, Massachusetts, United States Recruiting
• University of New Mexico Health Sciences Center
  Albuquerque, New Mexico, United States Recruiting
• Hospital Geral de Fortaleza
  Fortaleza, Brazil Recruiting
• Universidade Federal de Sǎo Paulo
  São Paulo, Brazil Recruiting
• University of Alberta Hospital
  Edmonton, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Daniel Roy, MD — CHUM-Montreal
• Study coordinator: Daniel Roy, MD
• Email: daniel.roy.chum@ssss.gouv.qc.ca
• Phone: 514-890-8000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Exploratory look at brain blood flow and metabolism before and after removing unruptured AVMs

  This study tests brain perfusion and metabolism with PET imaging and neuropsychological tests in adults before and six months after surgical treatment for unruptured brain AVMs.

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• Observational study on patients undergoing endovascular treatment for vascular conditions

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• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Registry for patients with Hereditary Hemorrhagic Telangiectasia

  This study is collecting information from people with Hereditary Hemorrhagic Telangiectasia to better understand the condition and help improve treatments in the future.

  Recruiting at 16 sites Cure HHT · Birmingham, Alabama and 15 other locations · NCT06259292

• Targeted therapies for patients with vascular malformations

  This study is testing new targeted treatments for patients with slow-flow and fast-flow vascular malformations to see if they work better than the usual therapies.

  Recruiting at 2 sites Phase 2 Murdoch Childrens Research Institute · Parkville, Victoria and 1 other locations · NCT05983159

• Evaluating the safety and usability of BALT medical devices for various brain and vascular conditions

  This study is testing how safe and effective BALT medical devices are for treating brain and blood vessel conditions like aneurysms and strokes.

  Recruiting at 10 sites Balt Extrusion · Angers and 11 other locations · NCT04927156

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.