Exercise to lower blood fats and improve blood-vessel health in young people with obesity

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants who are starting the Healthworks! structured weight-loss program will follow an exercise intervention and wear a Garmin Vivosmart tracker for one week at a time on three occasions during the six-month study. The team will collect device activity data, perform laser Doppler blood-flow testing, and use a Veggie Meter to estimate vegetable intake at baseline and at six months, alongside routine blood draws and clinical assessments from the Healthworks! visits. Text-message reminders will be sent for visit scheduling and daily at-home procedure prompts, and study visits are expected to last about an hour and may be scheduled separately from clinical visits. The protocol focuses on changes in blood lipid levels and endothelial (blood-vessel) function over the study period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age: 10-20 years
2. Obesity as defined by BMI ≥ 30 kg/m2 OR BMI ≥ 95%ile for age and sex
3. Planned to start the Healthworks! structured weight loss program.
4. English or Spanish speaking -

Exclusion Criteria:

1\. Physician judgement about inability to finish the protocol

\-

Where it's running

• Cincinnati Children's Hospital Medical Center
  Cincinnati, Ohio, United States Recruiting

Study contacts

• Study coordinator: Jordan Sill, MD
• Email: jordan.sill@cchmc.org
• Phone: 513-636-4200

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How incretin treatments affect muscle mass and function in people with overweight or obesity

  This study will see how drugs like semaglutide and tirzepatide influence fat-free mass, muscle strength, and physical function in adults with overweight or obesity.

  Recruiting Radboud University Medical Center · Amsterdam and 1 other locations · NCT07929831

• Dose find for remimazolam plus alfentanil for gastroscopy in obese adults

  This trial tests what dose of remimazolam besylate with alfentanil best sedates obese adults during gastroscopy.

  Recruiting Qianfoshan Hospital · Jinan, Shandong · NCT07925684

• Two-Year Weight Loss With GLP-1 Medications Compared With Sleeve Gastrectomy in Adults

  This study compares how much weight adults lose over two years when starting GLP-1 medicines versus adults who had sleeve gastrectomy at the same center.

  Recruiting Yuzuncu Yil University · Van · NCT07901777

• Gut barrier and inflammation after fast-food overfeeding in adults

  This study tests whether 14 days of fast-food overfeeding can alter gut barrier function and trigger inflammation in adults who are generally healthy.

  Recruiting University Hospital, Gentofte, Copenhagen · Hellerup · NCT07893743

• High BMI and periodontitis in Thai adults under 60

  This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.

  Recruiting Mahidol University · Bangkok, Ratchathewi · NCT07880717

• GLP-1 weight‑loss medicine: finding who will benefit most

  This study tests whether a GLP-1 drug called semaglutide helps with weight loss by changing eating behavior, to see which people it helps the most.

  Recruiting Phase 4 Universitaire Ziekenhuizen KU Leuven · Leuven · NCT07870538

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.