Exercise intervention for lung regeneration in COPD patients
Activation of Regenerative Pathways by Exercise Training in Patients With Chronic Obstructive Pulmonary Disease
This study is testing if a special exercise program can help improve lung function and overall health in people with COPD by promoting lung healing.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 50 Years to 85 Years |
| Sex | All |
| Sponsor | Uppsala University Academic / other |
| Locations | 2 sites (Lund and 1 other locations) |
| Trial ID | NCT06335992 on ClinicalTrials.gov |
What this trial studies
This project aims to explore how exercise training can promote lung regeneration in patients with Chronic Obstructive Pulmonary Disease (COPD). The study will evaluate biomarkers related to inflammation, stem cell activity, and tissue regeneration in lung biopsies, blood, and urine samples before and after an exercise program. It hypothesizes that tailored exercise can improve lung function and overall physical capacity by reducing oxidative stress and inflammation. The research also seeks to identify potential targets for future interventions based on the findings.
Who should consider this trial
Good fit: Ideal candidates include COPD patients with a forced expiratory volume (FEV1) between 30-85% of predicted, who are non-smokers and free from exacerbations.
Not a fit: Patients with unstable cardiovascular or pulmonary diseases or those who regularly participate in specialized exercise programs may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance lung function and quality of life for COPD patients through improved exercise capacity and reduced inflammation.
How similar studies have performed: While the approach of using exercise for COPD management is supported by recent guidelines, the specific molecular mechanisms and biomarkers being studied are novel and less explored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Forced expiratory volume in one second (FEV1) 85-30 % of predicted post bronchodilator * Optimal medical treatment according to GOLD and the Swedish National Guidelines * Absence of other significant diseases that could contribute to physical exercise limitation * Non-smoking since at least one year * Free from exacerbations (last 4 weeks) * BMI = 18- 35 Exclusion Criteria: * Regular participation in adjusted/specially designed exercise sessions * Unstable cardiovascular or pulmonary disease * Smoking * Any other criteria that at the discretion of the investigator prevent the study subject from participating in an exercise-training program
Where this trial is running
Lund and 1 other locations
- Lund University — Lund, Sweden (Recruiting)
- Uppsala University — Uppsala, Sweden (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.