Exercise intervention for lung regeneration in COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to explore how exercise training can promote lung regeneration in patients with Chronic Obstructive Pulmonary Disease (COPD). The study will evaluate biomarkers related to inflammation, stem cell activity, and tissue regeneration in lung biopsies, blood, and urine samples before and after an exercise program. It hypothesizes that tailored exercise can improve lung function and overall physical capacity by reducing oxidative stress and inflammation. The research also seeks to identify potential targets for future interventions based on the findings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Forced expiratory volume in one second (FEV1) 85-30 % of predicted post bronchodilator
* Optimal medical treatment according to GOLD and the Swedish National Guidelines
* Absence of other significant diseases that could contribute to physical exercise limitation
* Non-smoking since at least one year
* Free from exacerbations (last 4 weeks)
* BMI = 18- 35

Exclusion Criteria:

* Regular participation in adjusted/specially designed exercise sessions
* Unstable cardiovascular or pulmonary disease
* Smoking
* Any other criteria that at the discretion of the investigator prevent the study subject from participating in an exercise-training program

Where it's running

• Lund University
  Lund, Sweden Recruiting
• Uppsala University
  Uppsala, Sweden Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.