µQFR to check side‑branch narrowing after a single stent in bifurcation coronary arteries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study at Zhongshan Hospital, Fudan University will enroll adults with angiographically confirmed true coronary bifurcation lesions treated with a single‑stent strategy. Investigators will derive µQFR from single‑view angiography images after percutaneous coronary intervention and determine its diagnostic performance for side‑branch stenosis compared with routine physiological assessments. Eligible lesions must have a side branch diameter ≥2.5 mm and visually estimated stenosis ≥50%; patients with acute MI, cardiogenic shock, severe renal dysfunction, or contrast allergy are excluded. The goal is to clarify how reliably µQFR reflects side‑branch physiology in the altered hemodynamic environment created by bifurcation stenting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years and provision of written informed consent for biospecimen donation upon hospital admission.
2. Clinical suspicion or diagnosis of CAD requiring coronary angiography and physiological assessment.
3. Angiographically confirmed true bifurcation lesions, including but not limited to: left main-left anterior descending-left circumflex (LM-LAD-LCx), left anterior descending-diagonal (LAD-Dg), left circumflex-obtuse marginal (LCx-OM), and right coronary artery-posterior left ventricular-posterior descending artery (RCA-PLV-PDA).
4. Bifurcation lesion vessel diameter ≥ 2.5 mm with visually estimated angiographic diameter stenosis ≥ 50%.

Exclusion Criteria:

1. Acute myocardial infarction.
2. Cardiogenic shock or severe heart failure (Killip class IV).
3. Serum creatinine \> 150 μmol/L or estimated glomerular filtration rate (eGFR) \< 45 mL/min/1.73 m² calculated using the CKD-EPI formula.
4. Known allergy to iodinated contrast media.
5. History of coronary artery bypass graft surgery.

Where it's running

• Zhongshan Hospital, Fudan University
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Chenguang Li, MD, PhD
• Email: li.chenguang@zs-hospital.sh.cn
• Phone: 008664041990

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using intracoronary imaging more often to improve outcomes of complex coronary stenting

  This project tests whether more frequent use of intracoronary imaging during complex stenting procedures for adults with complicated coronary artery disease leads to better stent results and fewer major complications.

  Recruiting Cathreine BV · Eindhoven, North Brabant · NCT07114393

• Comparing two methods for treating significant left main coronary artery disease

  This study is testing whether two different ways of treating serious left main coronary artery disease can lead to better heart health for patients over two years.

  Recruiting at 38 sites Asan Medical Center · Hong Kong and 48 other locations · NCT05829889

• μFR-guided Drug-Coated Balloon Angioplasty vs Angiography-guided Angioplasty in Coronary Artery Disease

  This trial tests whether using computational μFR guidance during drug-coated balloon angioplasty is better than standard angiography guidance for people with de novo coronary artery lesions.

  Recruiting Centro Cardiologico Monzino · Cosenza, CS and 3 other locations · NCT07917234

• Gastric Ultrasound Before CABG to See if Heart Function Changes Stomach Contents

  This study checks whether people with weaker heart function before elective CABG have different stomach contents seen on ultrasound.

  Recruiting Adiyaman University · Adıyaman · NCT07898215

• Can preoperative photon-counting CT help predict heart recovery after bypass surgery?

  This observational study tests whether a preoperative photon-counting CT can help predict heart function 3 months after coronary bypass surgery in adults with coronary artery disease.

  Recruiting Chinese PLA General Hospital · Beijing · NCT07883499

• Real-World Drug-Coated Balloon Angioplasty in Coronary Artery Disease

  This registry tests how drug-coated balloons perform in everyday clinical practice for adults with coronary artery disease undergoing PCI.

  Recruiting at 5 sites Hospital Arnau de Vilanova · Mexico City, Mexico City and 4 other locations · NCT07875088

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.