Examining the effects of marijuana and opioids on each other
Modulation of Drug Intake: Evaluation of Opioid and Cannabinoid Interactions on Drug Self-Administration
This study tests how marijuana and oxycodone affect each other when taken together in healthy volunteers to see what happens.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 12 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | University of Kentucky Academic / other |
| Locations | 1 site (Lexington, Kentucky) |
| Trial ID | NCT05485012 on ClinicalTrials.gov |
What this trial studies
This study investigates how marijuana influences the self-administration of oxycodone and vice versa in healthy participants. Conducted in a controlled laboratory setting, participants will be administered varying doses of both substances to observe their interactions. The study aims to provide insights into the potential modulation effects between marijuana and opioids. Participants will reside at the University of Kentucky Hospital for approximately 6.5 weeks, where meals will be provided.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-50 with experience using both marijuana and opioids.
Not a fit: Patients with significant medical complications or conditions will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the interactions between marijuana and opioids, potentially informing safer prescribing practices.
How similar studies have performed: While there is ongoing research into the interactions between marijuana and opioids, this specific approach is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 18-50 * Experience with marijuana and opioids * General good health * Willing to live at the University of Kentucky Hospital (research unit) for approx. 6.5 weeks (meals are provided, Exclusion Criteria: * Significant medical complications/conditions
Where this trial is running
Lexington, Kentucky
- University of Kentucky — Lexington, Kentucky, United States (Recruiting)
Study contacts
- Principal investigator: Shanna Babalonis, PhD — University of Kentucky
- Study coordinator: Paul Nuzzo
- Email: pnuzz2@email.uky.edu
- Phone: (859) 323-0002
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.