Examining sleep disorders in Parkinson's disease and related conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates sleep disturbances in patients with isolated REM Behavior Disorder and Parkinson's disease. It aims to systematically assess the clinical characteristics and electrophysiological patterns of major sleep disorders associated with these conditions. Participants will undergo polysomnography to gather detailed sleep data. The study includes individuals diagnosed with Parkinson's disease, those with REM sleep behavior disorder, and healthy controls for comparison.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Common to all groups:

* Age superior 18 years
* Patients who have received complete information about the study from an investigator and who fully consent to participate.

For Parkinson Disease (PD):

* Patients followed for PD diagnosed according to international criteria for the diagnosis of PD (MDS criteria),
* A MoCA score greater than 20/30
* No treatment with deep brain stimulation.

For REM Sleep Behavior Disorder (RBD):

* Diagnosis of RBD according to ICSD-3 criteria: presence on polysomnography of an abnormal elevation of muscle tone during REM sleep (more than 18% of REM sleep without chin atonia) and/or the presence of REM sleep behaviors on video-polysomnography,
* Absence of progressive neurodegenerative pathology: absence of diagnostic criteria for PD, multiple system atrophy, or Lewy body dementia.

For healthy controls:

\- No neurological or psychiatric disease

Exclusion Criteria:

Common to all groups:

* Pregnant or breastfeeding women
* Subjects under guardianship/conservatorship
* Persons deprived of liberty.

Where it's running

• CHU de Clermont-Ferrand
  Clermont-Ferrand, France Recruiting
• CHU de Lille
  Lille, France Recruiting
• CHU de Lyon
  Lyon, France Recruiting
• CHU de Nantes
  Nantes, France Recruiting
• CHU de Nîmes
  Nîmes, France Recruiting
• CHU Pitié Salpêtrière
  Paris, France Recruiting

Study contacts

• Study coordinator: Isabelle ARNULF, Prof
• Email: isabelle.arnulf@aphp.fr
• Phone: +33 (0)1 42 16 77 04

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.