Examining memory and brain changes after aneurysmal subarachnoid hemorrhage
Investigation of the Relationship Between Hippocampal Volume and Memory Functions in in Patients With Aneurysmal Subarachnoid Hemorrhage (aSAH)
This study is testing how brain changes after a brain bleed affect memory in patients recovering from aneurysmal subarachnoid hemorrhage to help improve their rehabilitation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | BDH-Klinik Hessisch Oldendorf Academic / other |
| Locations | 1 site (Hessisch Oldendorf) |
| Trial ID | NCT04449666 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the long-term neuropsychological effects of aneurysmal subarachnoid hemorrhage (aSAH), particularly focusing on memory deficits and their potential association with hippocampal atrophy. The study will include 29 patients undergoing neurological rehabilitation, who will receive neuropsychological assessments and structural MRI scans within the first week of enrollment. By examining these relationships in the acute phase of recovery, the study aims to clarify the discrepancy between memory impairments and normal structural imaging results. The findings could provide insights into cognitive rehabilitation strategies for affected patients.
Who should consider this trial
Good fit: Ideal candidates are neurological rehabilitation patients with aneurysmal subarachnoid hemorrhage classified as Hunt & Hess grade I or II, at least eight weeks post-disease onset.
Not a fit: Patients with previous brain damage, significant mental disorders, or those unable to undergo MRI due to contraindications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment of memory deficits in patients recovering from aneurysmal subarachnoid hemorrhage.
How similar studies have performed: Previous studies have indicated a relationship between memory dysfunction and hippocampal atrophy, but this specific approach in the acute phase is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * neurological rehabilitation patients in phase B - D * at minimum eight weeks after disease onset * aneurysmal subarachnoid hemorrhage (Hunt \& Hess grade I or II) * written consent from the patient's legal representative * exclusion of pregnancy Exclusion Criteria: * insufficient cardiorespiratory stability * previous brain damage * mental disorders (dementia, depression) * colonization with multi-resistant pathogens * MRI contraindications * claustrophobia * weight \> 120 kg
Where this trial is running
Hessisch Oldendorf
- BDH-Clinic Hessisch Oldendorf — Hessisch Oldendorf, Germany (Recruiting)
Study contacts
- Principal investigator: Melanie Boltzmann, PhD — BDH-Clinic Hessisch Oldendorf
- Study coordinator: Melanie Boltzmann, PhD
- Email: m.boltzmann@bdh-klinik-hessisch.oldendorf
- Phone: 0049 5152 781 256
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.