Examining how gender affects distress and fatigue in cancer patients

Effect of Gender on Distress and Fatigue Over Time in Cancer Patients. A Prospective Longitudinal Study.

Observational Ente Ospedaliero Ospedali Galliera · NCT05122052

This study looks at how being male or female affects feelings of stress and tiredness in cancer patients over time, while also checking how these feelings relate to their response to COVID-19 vaccines.

Quick facts

Study typeObservational
Enrollment500 (estimated)
SexAll
SponsorEnte Ospedaliero Ospedali Galliera Academic / other
Locations1 site (Genova)
Trial IDNCT05122052 on ClinicalTrials.gov

What this trial studies

This observational study aims to investigate the impact of gender on psychological distress and fatigue in cancer patients over time. It hypothesizes that women will initially report higher levels of distress compared to men, but this trend may reverse during follow-up due to differing coping mechanisms. The study will also explore the relationship between psychological factors and immune response to COVID-19 vaccination. By understanding these dynamics, the research seeks to inform targeted psychological support for cancer patients.

Who should consider this trial

Good fit: Ideal candidates include cancer patients of any type and stage who are willing to participate in psychological interviews.

Not a fit: Patients who are not undergoing treatment for cancer or those who are not willing to participate in psychological assessments may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved psychological support strategies tailored to the needs of cancer patients based on gender.

How similar studies have performed: While there is existing literature on gender differences in distress among cancer patients, this longitudinal approach focusing on time-related changes is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with cancer of any site and stage willing to undergo a psychological interview before the medical visit, including those receiving COVID-19 vaccine.

Exclusion Criteria:

* None

Where this trial is running

Genova

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Cancerdistressgenderfatiguetimeeffect modification
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.