Examining blood pressure treatment in ICU patients with brain hemorrhage
Blood Pressure Treatment in ICU Patients with Subarachniodal Haemorrhage. -Can Blood Pressure Be Used As a Surrogate Marker for Blood Flow
This study tests how changing blood pressure affects blood flow in the brains of ICU patients who have had a brain hemorrhage.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Umeå University Academic / other |
| Locations | 1 site (Umeå) |
| Trial ID | NCT06033378 on ClinicalTrials.gov |
What this trial studies
This study investigates the relationship between blood pressure and cerebral blood flow in patients with subarachnoid hemorrhage (SAH) who may experience vasospasm. Using MRI techniques, the study aims to measure cerebral blood flow at baseline blood pressure and after increasing mean arterial pressure with norepinephrine. The goal is to understand how changes in blood pressure affect cerebral blood flow in this critical patient population. The findings could help optimize blood pressure management in ICU settings for patients with SAH.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with a coiled or clipped aneurysm and suspected or confirmed vasospasm.
Not a fit: Patients with a BMI over 30, pregnancy, or severe cardiac or respiratory conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved blood pressure management strategies that enhance cerebral blood flow and reduce mortality in patients with subarachnoid hemorrhage.
How similar studies have performed: Other studies have explored blood pressure management in similar contexts, but this specific approach using MRI to correlate blood pressure and cerebral blood flow in SAH patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Coiled or clipped aneurysm * Suspected or confirmed vasospasm Exclusion Criteria: * BMI \>30 * Pregnancy * Pacemaker or other MRI contraindications * Severe congestive heart failure (NYHA III-IV) or cardiac arrhythmia. * Severe respiratory failure or FiO2 \>0.6 * Severe kidney failure
Where this trial is running
Umeå
- Umeå University Hospital — Umeå, Sweden (Recruiting)
Study contacts
- Principal investigator: Laleh Zarrinkoob — Region Västerbotten
- Study coordinator: Laleh Zarrinkoob, MD, PhD
- Email: laleh.zarrinkoob@umu.se
- Phone: +46707567067
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.