Examining blood markers and clotting factors in patients on ECMO support
DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
This study is trying to see how certain blood markers and clotting factors relate to complications in adults on ECMO support in intensive care units.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | N/A to 80 Years |
| Sex | All |
| Sponsor | Queen Mary Hospital, Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT06095518 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the relationship between novel disseminated intravascular coagulation (DIC) markers and thrombin generation parameters in patients receiving extracorporeal membrane oxygenation (ECMO) support. By analyzing these correlations, the study seeks to understand how they relate to thrombotic and hemorrhagic complications that may arise during ECMO treatment. The research will be conducted in the intensive care units of Queen Mary Hospital and Tuen Mun Hospital in Hong Kong, focusing on adult patients requiring either veno-arterial or veno-venous ECMO support.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are admitted to the intensive care units and require ECMO support.
Not a fit: Patients on central VA-ECMO support or those with pre-existing thromboembolism requiring long-term anticoagulation prior to ECMO cannulation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of thrombotic and hemorrhagic complications in patients on ECMO support.
How similar studies have performed: While this study explores novel markers in a specific context, similar studies have shown promise in understanding coagulation complications in ECMO patients.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≧ 18; AND * Admitted to the mixed medical-surgical intensive care units of Queen Mary Hospital or Tuen Mun Hospital in Hong Kong; AND * Require either veno-arterial (VA) or veno-venous (VV) extracorporeal membrane oxygenation (ECMO) support. Exclusion Criteria: * Patients who are on central VA-ECMO support; OR * Patients with missing clinical data; OR * Patients with pre-existing thromboembolism requiring long term anticoagulation prior to ECMO cannulation; OR * Post-operative admissions
Where this trial is running
Hong Kong
- Queen Mary Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Study coordinator: Wincy Ng
- Email: wincyngwingsze@gmail.com
- Phone: +852-22553111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.