Examining amino acid loss in patients undergoing kidney treatment
Amino Acid Effluent Loss During Continuous Renal Replacement Therapy: an Explorative Non-interventional Pilot Study
This study looks at how much amino acid is lost in patients receiving kidney treatment in the ICU compared to those who aren't, to help improve nutrition for people with kidney problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna, State of Vienna) |
| Trial ID | NCT06659835 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the loss of amino acids during continuous renal replacement therapy (CRRT) in intensive care patients. It will measure amino acid concentrations in both the effluent from the CRRT machine and the plasma of patients receiving CRRT, as well as in a control group of patients not undergoing this therapy. The study will involve 20 patients on CRRT and 10 patients without renal replacement therapy, assessing changes in amino acid levels over time and monitoring various health parameters. The findings could provide insights into nutritional management for patients with renal insufficiency.
Who should consider this trial
Good fit: Ideal candidates include postoperative ICU patients aged 18 and older who are receiving enteral or parenteral nutrition and are planned for CRRT.
Not a fit: Patients with chronic kidney disease stages G3-G5 or those with liver cirrhosis or acute liver failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance nutritional strategies for critically ill patients undergoing renal replacement therapy.
How similar studies have performed: While this study explores a specific aspect of amino acid loss in CRRT, similar studies have not extensively addressed this particular focus, making it a novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Postoperative ICU patients * Age ≥ 18 years * Patients on enteral or/and parenteral nutrition given according to internal standard operating procedure A) CRRT group: \- CRRT treatment planned; all types of CRRT (continuous veno-venous hemodialysis (CVVHD), continuous veno-venous hemodiafiltration (CVVHDF), continuous veno-venous hemofiltration (CVVH)) B)Non-CRRT group: * no current or previous (\<30 days) continuous or intermittent RRT * no chronic kidney disease stage G3-G5 Exclusion criteria: * Preoperative intensive care patients * Patients with liver cirrhosis stage 1-3 according to the Child-Pugh classification * Patients with acute liver failure
Where this trial is running
Vienna, State of Vienna
- Medical University of Vienna — Vienna, State of Vienna, Austria (Recruiting)
Study contacts
- Principal investigator: Sarah Yadavalli, Dr. — Medical University of Vienna
- Study coordinator: Sarah Yadavalli, Dr.
- Email: sarah.yadavalli@meduniwien.ac.at
- Phone: +43 67761632558
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.