Evaluating the effects of lying on the stomach for patients with severe lung issues
Assessment of the Effects of Prone Positioning Among ARDS Patients on Ventilation Homogenization by the Phase Iii Slope of the Volumetric Capnography
This study is testing if lying on the stomach can help improve lung function in patients with severe breathing problems caused by Acute Respiratory Distress Syndrome.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Istanbul University - Cerrahpasa Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT05535543 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how prone positioning affects the ventilation of patients suffering from Acute Respiratory Distress Syndrome (ARDS). Eligible patients, who are intubated and mechanically ventilated, will undergo a series of assessments including pressure volume curves and recruitment ratios. The study will record the phase III slope of volumetric capnography at four different time points: before and after turning the patient to a prone position, and after returning to a supine position. This approach aims to determine the effectiveness of prone positioning in improving lung function in ARDS patients.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who meet the criteria for ARDS and require mechanical ventilation.
Not a fit: Patients with chronic pulmonary diseases, significant hemodynamic instability, or those not expected to survive beyond 24 hours may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with ARDS, potentially enhancing their respiratory function.
How similar studies have performed: Previous studies have shown that prone positioning can improve outcomes in ARDS patients, suggesting that this approach may be beneficial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ARDS criteria met * intubated and mechanically ventilated as a result of respiratory failure * PaO2/FiO2 \<200 Exclusion Criteria: * age older than 18 * Chronic pulmonary disease, pneumothoraces, intraabdominal hypertension (\> 12 mmHg), pregnancy, not expected to survive \>24 hours, hemodynamic instability
Where this trial is running
Istanbul
- Hamidiye Etfal Hospital — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Olcay Dilken, MD — Hamidiye Etfal Hospital
- Study coordinator: Olcay Dilken, MD
- Email: olcaydilken@gmail.com
- Phone: +905547378709
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.