Evaluating pneumococcal vaccination responses in heart transplant candidates
Official title: Response to Guideline-concordant Pneumococcal Vaccination Strategy in Cardiac Transplant Candidates and Recipients
Run by Montefiore Medical Center · NCT04845945 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests how well pneumococcal vaccines work in people being evaluated for a heart transplant, including those with a left ventricular assist device, to see if the current vaccination methods are good enough for them.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | Montefiore Medical Center Academic / other |
| Locations | 1 site (Bronx, New York) |
| Trial ID | NCT04845945 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and over who are either being evaluated for a heart transplant or have already received one.
✕Probably not a fit
Patients who are under 18, pregnant, or already up to date on pneumococcal vaccination will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the immune response to pneumococcal vaccination in patients undergoing evaluation for heart transplant, including those who have received a left ventricular assist device (LVAD). Participants will receive vaccinations according to standard care guidelines, while their responses will be assessed using two blood tests: ELISA and OPA. The study aims to determine if current vaccination strategies are sufficient for this high-risk population. Participation involves minimal additional risk, primarily associated with blood sample collection.
Why it matters
Potential benefit: If successful, this study could improve vaccination strategies for heart transplant candidates, enhancing their infection prevention.
How similar studies have gone: While this approach is observational and builds on existing vaccination guidelines, similar studies have shown the importance of tailored vaccination strategies in immunocompromised populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 or over * Either undergoing evaluation for heart transplant (with or without LVAD receipt), or having received a heart transplant * Receiving a dose of PCV15 or PPSV23 (or both sequentially) concordant with AST guidelines Exclusion Criteria: * Infants and children under age 18 * Subjects without the capacity to consent * Pregnancy * Already up to date on pneumococcal vaccination or declining vaccination
Where it's running
-
Montefiore Medical Center, Infectious Diseases
Bronx, New York, United States Recruiting
Study contacts
- Principal investigator: Vagish Hemmige, MD — Montefiore Medical Center
- Study coordinator: Vagish Hemmige, MD
- Email: vahemmig@montefiore.org
- Phone: 718-920-2705
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.