Clinical trial Recruiting at 1 site Observational Ages 18 and up

Evaluating new methods for detecting exercise-induced heart issues

Official title: BASEL VIII Trial - Biochemical and Electrocardiographic Signatures in the Detection of Exercise-induced Myocardial Ischemia

Run by University Hospital, Basel, Switzerland · NCT01838148 · Data updated 2026-11-12

This study is testing new ways to spot heart problems that can happen during exercise to see if they work better than the usual methods and can help predict long-term heart risks.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment4000 (estimated)
SponsorUniversity Hospital, Basel, Switzerland
Academic / other
Drugs / interventionsradiation
Locations1 site (Basel)
StatusRecruiting
StartedMay 2004
Main results expectedDecember 2025
Study endsDecember 2025
Registry record updatedJuly 11, 2025
Trial IDNCT01838148 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients suspected of having exercise-induced myocardial ischemia who are referred for myocardial perfusion SPECT testing.

Probably not a fit

Patients under 18 years old, pregnant women, or those unable to provide informed consent will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to be the largest global effort to assess new biochemical and electrocardiographic signatures, both individually and in combination with standard 12-lead exercise ECG, for detecting exercise-induced myocardial ischemia. It also seeks to evaluate these innovative tools for predicting long-term risks of cardiovascular death and acute myocardial infarction. The study addresses the limitations of current diagnostic methods, which can be costly and expose patients to significant risks. By leveraging advances in technology and signal processing, the research hopes to enhance the accuracy of detecting coronary artery disease.

Why it matters

Potential benefit: If successful, this study could lead to more accurate and safer methods for diagnosing coronary artery disease, ultimately improving patient outcomes.

How similar studies have gone: Other studies have explored similar approaches, but this study aims to be the largest and most comprehensive, potentially offering novel insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients presenting with suspected exercise-induced myocardial ischemia referred for rest/ergometry myocardial perfusion SPECT

Exclusion Criteria:

* Age \< 18 years
* Pregnancy
* Unable or unwilling to give informed consent
* Symptoms at rest or minor exertion

Where it's running

  • University Hospital Basel
    Basel, Switzerland
    Recruiting

Study contacts

  • Principal investigator: Christian Mueller, Prof. Dr. MD — University Hospital, Basel, Switzerland
  • Study coordinator: Christian Mueller, Prof. Dr. MD
  • Email: Christian.Mueller@usb.ch
  • Phone: + 41 61328 65 49

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.