Evaluating new methods for detecting exercise-induced heart issues
BASEL VIII Trial - Biochemical and Electrocardiographic Signatures in the Detection of Exercise-induced Myocardial Ischemia
This study is testing new ways to spot heart problems that can happen during exercise to see if they work better than the usual methods and can help predict long-term heart risks.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 4000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Basel) |
| Trial ID | NCT01838148 on ClinicalTrials.gov |
What this trial studies
This study aims to be the largest global effort to assess new biochemical and electrocardiographic signatures, both individually and in combination with standard 12-lead exercise ECG, for detecting exercise-induced myocardial ischemia. It also seeks to evaluate these innovative tools for predicting long-term risks of cardiovascular death and acute myocardial infarction. The study addresses the limitations of current diagnostic methods, which can be costly and expose patients to significant risks. By leveraging advances in technology and signal processing, the research hopes to enhance the accuracy of detecting coronary artery disease.
Who should consider this trial
Good fit: Ideal candidates are patients suspected of having exercise-induced myocardial ischemia who are referred for myocardial perfusion SPECT testing.
Not a fit: Patients under 18 years old, pregnant women, or those unable to provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and safer methods for diagnosing coronary artery disease, ultimately improving patient outcomes.
How similar studies have performed: Other studies have explored similar approaches, but this study aims to be the largest and most comprehensive, potentially offering novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting with suspected exercise-induced myocardial ischemia referred for rest/ergometry myocardial perfusion SPECT Exclusion Criteria: * Age \< 18 years * Pregnancy * Unable or unwilling to give informed consent * Symptoms at rest or minor exertion
Where this trial is running
Basel
- University Hospital Basel — Basel, Switzerland (Recruiting)
Study contacts
- Principal investigator: Christian Mueller, Prof. Dr. MD — University Hospital, Basel, Switzerland
- Study coordinator: Christian Mueller, Prof. Dr. MD
- Email: Christian.Mueller@usb.ch
- Phone: + 41 61328 65 49
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.