Evaluating neck anatomy function during thyroid surgery
Official title: Preserving Function Integrity of Neck Anatomy in Thyroid Surgery: A Randomized Clinical Trial
Run by Wuhan University · NCT04666103 · Data updated 2026-11-12
This study is testing if using heat treatment during thyroid surgery can help patients with low-risk thyroid cancer and benign nodules avoid having their entire thyroid removed.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 1264 (estimated) |
| Sponsor | Wuhan University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Wuhan, Hubei) |
| Status | Recruiting |
| Started | December 11, 2020 |
| Main results expected | December 31, 2021 |
| Study ends | December 12, 2026 |
| Registry record updated | December 14, 2020 |
| Trial ID | NCT04666103 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients diagnosed with unilateral thyroid carcinoma and a benign contralateral nodule confirmed by fine-needle aspiration.
✕Probably not a fit
Patients with a history of neck surgery or neck radiation therapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of intraoperative thermal ablation for treating benign thyroid nodules in patients undergoing lobectomy for unilateral thyroid carcinoma. It aims to determine whether this approach can reduce the need for total thyroidectomy, which may be considered overtreatment for some patients. By focusing on patients with low-risk papillary thyroid carcinoma and benign contralateral nodules, the study seeks to improve quality of life and minimize complications associated with thyroid surgery. The methodology involves assessing the outcomes of patients who receive thermal ablation during their surgical procedure.
Why it matters
Potential benefit: If successful, this approach could reduce unnecessary surgeries and improve the quality of life for patients with thyroid conditions.
How similar studies have gone: Other studies have shown promising results with thermal ablation techniques, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with unilateral thyroid carcinoma and contralateral benign nodule confirmed by preoperative ultrasound-guided fine-needle aspiration cytology; * Patients with contralateral nodules ≤ 20mm and located in the thyroid gland; * Patients with clinical node-negative cervical compartment at palpation and neck ultrasound. Exclusion Criteria: * Previous history of neck surgery * Previous history of neck radiation therapy
Where it's running
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Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China Recruiting
Study contacts
- Principal investigator: Gaosong Wu, Ph.D. — Department of Breast and Thyroid Surgery, Zhongnan Hospital of Wuhan University
- Study coordinator: Qianqian Yuan, M.D.
- Email: Yuanqq11@whu.edu.cn
- Phone: 13026322297
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.