Evaluating mobility in patients with severe knee osteoarthritis before knee replacement surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess mobility in patients suffering from severe knee osteoarthritis who are scheduled for total knee replacement. Utilizing an innovative evaluation technique based on inertial sensors (X-SENS device), the researchers seek to better understand movement deficits in these patients. The study will involve measuring functional performance through wearable technology to capture a comprehensive view of mobility in daily activities. By identifying specific biomarkers related to functional improvement, the study hopes to enhance preoperative assessments and postoperative recovery strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient over 60 years old
* Presence of unilateral knee osteoarthritis (Kellgren and Lawrence radiographic stage ≥ 3) in the femorotibial compartment and/or Iwano stage ≥2 in the femoropatellar compartment);
* Average VAS (Visual Analogic Scale) pain on a reference joint (knee) \> 40/100 during the past month.
* Indication for prosthetic knee surgery (total knee replacement)
* Failure of a well-conducted medical treatment (at least one prior infiltration with corticoids or hyaluronic acid or PRP (Platelet-rich plasma))

Exclusion Criteria:

* Presence of an inflammatory joint disease (rheumatoid arthritis, spondyloarthritis, microcrystalline pathology)
* Presence of a post-traumatic gonarthrosis
* Frontal deformity of the lower limb \> 15
* Preoperative flessum \> 15° or preoperative knee mobility \< 90°
* Neurological pathology
* Spinal pathology that is painful or causes deformity (severe Cobb scoliosis \> 20°)
* History of trauma or surgery of the lower limbs in the last two years,
* Presence of at least one lower limb prosthesis (total hip or ankle prosthesis)
* Subject with a contraindication to MRI examination (pacemaker, neurosensory stimulators, cardiac defibrillator, cochlear implants, ferromagnetic ocular or cerebral foreign bodies...)
* Subjects with a contraindication to DXA examination (coronary stent or metallic cardiac sutures, pacemaker or automatic defibrillator, obesity with a BMI \> 35kg/m2, insulin pump, weight over 200kgs)
* Subject with a legal protection measure (guardianship, curatorship)
* Subject under legal protection
* Subject not affiliated to a social security system or not benefiting from such a system
* Absence of informed written consent

Where it's running

• University Hospital of Montpellier
  Montpellier, France Recruiting

Study contacts

• Study coordinator: Yves-Marie PERS, MD-PhD
• Email: ym-pers@chu-montpellier.fr
• Phone: 04.67.33.72.31

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.