Evaluating long-term effects of radiotherapy in cancer patients

Evaluation of Late Effects and Natural History of Disease in Patients Treated With Radiotherapy

Observational National Institutes of Health Clinical Center (CC) · NCT00026650

This study looks at the long-term effects of radiation treatment in cancer patients to see how it impacts their health over time.

Quick facts

Study typeObservational
Enrollment700 (estimated)
Ages18 Years and up
SexAll
SponsorNational Institutes of Health Clinical Center (CC) NIH
Drugs / interventionsradiation
Locations1 site (Bethesda, Maryland)
Trial IDNCT00026650 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the late effects of radiotherapy treatment and the natural history of disease in patients who have previously received radiation therapy at the National Cancer Institute. It involves collecting data from standard follow-up care procedures to understand the long-term outcomes and side effects associated with various cancer treatments. Participants will be monitored and their data may be used anonymously for research publications regarding disease processes and treatment effects.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who have received radiotherapy at the NCI and are not currently enrolled in an interventional research protocol.

Not a fit: Patients who are actively participating in an interventional research protocol at the time of enrollment will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the long-term health impacts of radiotherapy, potentially improving follow-up care for cancer survivors.

How similar studies have performed: Other studies have shown success in evaluating long-term effects of cancer treatments, making this approach both relevant and necessary for ongoing patient care.

Eligibility criteria

Show full inclusion / exclusion criteria
* INCLUSION CRITERIA:

ROB investigator deems that it is in the best interests of the participant and the NCI/ROB for the participant to be seen in follow-up in the ROB clinic.

Participant is able to provide informed consent.

Participant must have a primary physician in the community to whom records and appropriate follow-up management can be given. Social services will be enlisted for any participants who lack health insurance, etc.

Participants who have received radiotherapy.

Age greater than or equal to 18 years of age

EXCLUSION CRITERIA:

Participants who are on an interventional research protocol at NIH at the time of enrollment.

Where this trial is running

Bethesda, Maryland

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions CancerLate EffectsRadiation TherapyNatural History
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.