Evaluating liver fat improvement after weight loss surgery
Evaluation of Changes in Liver Fat Content and Exploration of Potential Effect Actors After Bariatric Surgery Based on MRI
This study is testing whether weight loss surgery can help reduce liver fat in obese patients with non-alcoholic fatty liver disease and how it relates to inflammation in the body.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 16 Years to 60 Years |
| Sex | All |
| Sponsor | The Affiliated Hospital of Qingdao University Academic / other |
| Locations | 1 site (Qingdao, Shandong) |
| Trial ID | NCT06064240 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the improvement of liver fat content in obese patients with non-alcoholic fatty liver disease (NAFLD) following laparoscopic sleeve gastrectomy. Utilizing advanced MRI techniques, the study will quantify liver status and explore the correlation between systemic inflammation and liver improvement post-surgery. Patients will be monitored at multiple time points: preoperatively, and at one, three, and six months post-surgery, to gather comprehensive data on liver health changes. The findings may provide new insights into the relationship between weight loss and liver health.
Who should consider this trial
Good fit: Ideal candidates are obese individuals aged 16 to 60 with a BMI greater than 32 kg/m2 and diagnosed with fatty liver disease.
Not a fit: Patients with secondary obesity, significant alcohol consumption, or other diseases affecting liver function may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could offer a new method for evaluating liver health in patients with fatty liver disease, potentially improving treatment strategies.
How similar studies have performed: While there have been studies on the effects of bariatric surgery on liver health, this specific approach using advanced MRI techniques is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 16 years old \< age \< 60 years old * BMI \> 32kg/m2 * No previous drinking history; weekly drinking of males \< 210g and females \< 140g in 12 months * Preoperative auxiliary examination supports the diagnosis of fatty liver, and liver MRI examination * Previous attempts to lose weight are ineffective * Complete case data. Exclusion criteria: * Secondary obesity * History of drinking or excessive drinking (in the past 12 months, male's weekly alcohol intake was ≥210g, female's weekly alcohol intake was ≥ 140g) * Other diseases causing abnormal liver function * Body mass index \< 28kg/m2 * Poor compliance or self-control, unable to follow the dietary guidance after operation * Those who cannot complete the follow-up
Where this trial is running
Qingdao, Shandong
- Qingdao University Affiliated Hospital — Qingdao, Shandong, China (Recruiting)
Study contacts
- Study coordinator: yu li, Dr
- Email: liyu11920@hotmail.com
- Phone: 18661809631
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.