Evaluating inflammation and clotting in coronary artery disease
Inflammation and Clotting Abnormalities in Aneurysmal Coronary Artery Disease
This study is testing how inflammation and clotting issues differ in people with coronary artery disease and those with both abdominal aortic aneurysm and coronary artery disease to see if these factors affect their health outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 180 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | John Paul II Hospital, Krakow Academic / other |
| Locations | 1 site (Krakow) |
| Trial ID | NCT05183373 on ClinicalTrials.gov |
What this trial studies
This project aims to assess inflammation and clotting abnormalities in patients with aneurysmal coronary artery disease compared to those with abdominal aortic aneurysm and coronary artery disease. The study will enroll 180 patients divided into three groups, with a focus on measuring inflammation biomarkers and fibrin clot properties. Additionally, up to 250 patients with aneurysmal coronary disease will be followed for clinical outcomes. The primary goal is to determine if there are significant differences in these parameters among the different patient cohorts.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-85 with confirmed coronary artery ectasia or aneurysm, abdominal aortic aneurysm, or coronary artery disease.
Not a fit: Patients with recent acute coronary syndrome, those on certain anticoagulant therapies, or with severe comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of aneurysmal coronary artery disease.
How similar studies have performed: While this study explores a specific aspect of coronary artery disease, similar studies have shown promise in understanding the role of inflammation and clotting in cardiovascular conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-85 years old * Angiographically confirmed coronary artery ectasia or aneurysm (Arm I) * Abdominal aortic aneurysm (Arm II) * Angiographically confirmed coronary artery disease (Arm III) Exclusion Criteria: * Less than 12 months from ACS * Actual oral anticoagulant therapy * Actual antiplatelet therapy other than aspirin * Heart failure NYHA IV * Untreated hyperthyroidism or hypothyroidism * Severe comorbidities * Lack of consent
Where this trial is running
Krakow
- Department of Cardiac and Vascular Diseases, John Paul II Hospital — Krakow, Poland (Recruiting)
Study contacts
- Principal investigator: Piotr Musiałek, MD, DPhil — John Paul II Hospital, Krakow
- Study coordinator: Piotr Musiałek, MD DPhil
- Email: p.musialek@szpitaljp2.krakow.pl
- Phone: +48126143501
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.