Evaluating His Bundle Pacing for Heart Conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with heart failure or bradycardia who are scheduled for pacemaker implantation. Participants will undergo procedures such as His bundle pacing or left bundle area pacing, and additional heart rhythm measurements will be collected during the implantation to assess the effects on electrical conduction. The study aims to understand how these pacing techniques can normalize atrioventricular conduction in patients with heart failure or AV block.

Why it matters

Who can join: the full rules

Inclusion Criteria:

HF Group

* Clinically recommended to undergo PM, CRT-P, or CRT-D implantation or HIBP/LBAP (including HIBP/LBAP for patients with HF, for patients who have failed CRT implant or patients who are CRT non-responders)
* Any QRS duration
* LVEF ≤ 50%

AV Block/Bradycardia Group

* Recommended to undergo dual chamber pacemaker implantation
* Any AV block or Sinus Bradycardia

Exclusion Criteria:

* Age \< 18 years
* Pregnant

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Yong-Mei Cha, M.D. — Mayo Clinic
• Study coordinator: Yong-Mei Cha, M.D.
• Email: ycha@mayo.edu
• Phone: (507) 255-2440

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Personalized pacemaker rate setting to improve symptoms in heart failure with bradycardia

  Researchers will try adjusting the pacemaker lower rate to a personalized, hemodynamically optimized heart rate to see if it reduces symptoms in people with heart failure who need a pacemaker.

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• BIOTRONIK CSP Lead Registry for Left Bundle Branch Area Pacing

  This registry tests BIOTRONIK’s CSP-based pacing lead in patients needing a pacemaker or CRT, to see how it performs in real-life use.

  Recruiting at 12 sites Biotronik SE & Co. KG · Adelaide and 45 other locations · NCT07393009

• Left bundle branch area pacing with Tendril STS or UltiPace leads

  This study will try left bundle branch area pacing with the Tendril STS or UltiPace lead in adults who need pacemaker leads for bradycardia or related heart conditions to see if pacing and sensing are safe and work through six months after implant.

  Recruiting at 13 sites Abbott Medical Devices · Rio de Janeiro, Rio de Janeiro and 14 other locations · NCT07217392

• Using Apple Watch data to predict heart failure outcomes

  This study is testing if data from Apple Watches can help predict heart failure problems and the chances of needing to go back to the hospital for patients with heart failure.

  Recruiting University Medical Center Goettingen · Goettigen, Lower Saxony · NCT06819618

• Ultra-high-frequency ECG to diagnose ventricular electrical dyssynchrony in patients getting pacemakers

  This test checks whether an ultra-high-frequency ECG can safely and accurately detect ventricular dyssynchrony in adults with bradycardia or heart failure who are having their first pacemaker implanted.

  Recruiting at 12 sites VDI Technologies · Avondale, Arizona and 11 other locations · NCT06641362

• Comparing Aortix Device to Diuretics for Acute Heart Failure

  This study is testing whether the Aortix device can help people with acute heart failure who aren't responding to diuretics feel better compared to standard treatment.

  Recruiting at 33 sites Procyrion · Phoenix, Arizona and 49 other locations · NCT05677100

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.