Evaluating heart transplant dysfunction using MRI and sequencing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess early signs of cardiac allograft dysfunction in heart transplant patients through cardiac MRI and single cell sequencing. Adult participants, who are at least three months post-heart transplantation and meet specific eligibility criteria, will undergo various imaging techniques and biopsies to identify molecular and macroscopic causes of dysfunction. The study will take place over 60 months at UC San Diego, with follow-up for major adverse cardiac events for at least one year after enrollment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age greater than or equal to 18 years old.
* At least three months status post heart transplantation.

Exclusion Criteria:

* Biopsy proven acute rejection episode in the past 3 months.
* Patients with symptoms or signs of acute myocardial ischemia or recent acute coronary syndrome in the past 3 months.
* Uncontrolled obstructive ventilatory disease including asthma and COPD.
* History of generalized tonic-clonic seizures.
* Second or third degree AV nodal block.
* Sinus node dysfunction.
* Contraindications to MRI including cardiovascular implantable electronic devices.
* Renal dysfunction with an estimated GFR less than 30 mL/min/1.73m2.
* Prior adverse reaction to either regadenoson or gadolinium contrast. Prior adverse reaction to adenosine or dipyridamole will be assessed on a case-by-case basis.
* Systolic blood pressure greater than 180 or less than 85 mmHg.
* Diastolic blood pressure greater than 120 or less than 40 mmHg.
* Resting heart rate greater than 120 or less than 45 beats per minute. - Severe claustrophobia.

Where it's running

• UC San Diego
  La Jolla, California, United States Recruiting

Study contacts

• Principal investigator: Paul Kim, MD — UC San Diego
• Study coordinator: Paul Kim, MD
• Email: pjk017@ucsd.edu
• Phone: 8582460638

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.