Exploring the link between lipid levels and organ rejection in heart transplant patients
A Prospective Clinical Study of Association Between Postoperative Dyslipidemia and Organ
This study is trying to see if problems with fat levels in the blood after a heart transplant can lead to organ rejection and affect how well patients do over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Academic / other |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (Wuhan) |
| Trial ID | NCT05994274 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between postoperative dyslipidemia and organ rejection in patients who have undergone heart transplantation. It aims to understand how abnormal lipid metabolism, which affects a significant number of transplant recipients, may contribute to transplant failure and patient mortality. The study will analyze lipid parameters and their potential mechanisms in the context of heart transplant rejection, focusing on factors like PCSK9 expression and immune response. By identifying these associations, the research seeks to provide insights into improving long-term outcomes for heart transplant patients.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have undergone heart transplantation and have experienced symptomatic heart failure for at least six months prior to screening.
Not a fit: Patients who refuse to provide consent or have another life-threatening disease with a poor prognosis may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management strategies for dyslipidemia in heart transplant patients, potentially reducing the risk of organ rejection and improving patient survival.
How similar studies have performed: While previous studies have indicated a connection between lipid levels and transplant rejection, this specific approach to understanding dyslipidemia in heart transplant patients is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * After heart transplantation * Age ≥ 18 * Disease duration: symptomatic heart failure ≥ 6 months prior to screening date * The patient's informed consent Exclusion Criteria: * Refusal of the patient to provide consent * Suspected poor capability to follow instructions and cooperate * Another life-threatening disease with poor prognosis (survival less than 2 years) * Participation in any other clinical study within less than 30 days prior to screening date
Where this trial is running
Wuhan
- Wuhan Union Hospital — Wuhan, China (Recruiting)
Study contacts
- Study coordinator: Jiahong Xia
- Email: jiahong.xia@mail.hust.edu.cn
- Phone: (+0086)13971038472
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.