Exploring the link between lipid levels and organ rejection in heart transplant patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between postoperative dyslipidemia and organ rejection in patients who have undergone heart transplantation. It aims to understand how abnormal lipid metabolism, which affects a significant number of transplant recipients, may contribute to transplant failure and patient mortality. The study will analyze lipid parameters and their potential mechanisms in the context of heart transplant rejection, focusing on factors like PCSK9 expression and immune response. By identifying these associations, the research seeks to provide insights into improving long-term outcomes for heart transplant patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* After heart transplantation
* Age ≥ 18
* Disease duration: symptomatic heart failure ≥ 6 months prior to screening date
* The patient's informed consent

Exclusion Criteria:

* Refusal of the patient to provide consent
* Suspected poor capability to follow instructions and cooperate
* Another life-threatening disease with poor prognosis (survival less than 2 years)
* Participation in any other clinical study within less than 30 days prior to screening date

Where it's running

• Wuhan Union Hospital
  Wuhan, China Recruiting

Study contacts

• Study coordinator: Jiahong Xia
• Email: jiahong.xia@mail.hust.edu.cn
• Phone: (+0086)13971038472

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Letermovir versus valganciclovir to prevent CMV after heart transplant

  This trial will test whether letermovir or valganciclovir better prevents CMV viremia in adults at moderate-to-high CMV risk after a heart transplant.

  Recruiting at 2 sites Phase 2/3 Columbia University · New York, New York and 1 other locations · NCT07079735

• Evaluating heart transplant dysfunction using MRI and sequencing

  This study is testing if heart scans and genetic analysis can help find early signs of problems in heart transplant patients to improve their care.

  Recruiting Phase 4 University of California, San Diego · La Jolla, California · NCT03102125

• Nationwide Swedish program testing donor-derived cell-free DNA to monitor rejection after heart transplant

  This project tests whether a blood test measuring donor-derived cell-free DNA can help monitor rejection in adults who have had a heart transplant.

  Recruiting Karolinska Institutet · Stockholm · NCT07531784

• Evaluating microvascular resistance in heart transplant patients

  This study tests if measuring blood flow in the small vessels of heart transplant patients can help reduce the need for repeated heart tissue tests.

  Recruiting Hospital Miguel Servet · L'Hospitalet de Llobregat, Barcelona and 1 other locations · NCT06656065

• Using mobile video to help young heart transplant patients take their medications

  This study tests whether using mobile videos can help young heart transplant patients remember to take their medications regularly.

  Recruiting at 3 sites University of Florida · Coral Gables, Florida and 3 other locations · NCT05732779

• Evaluating donor-derived DNA levels in heart transplant rejection

  This study is testing whether measuring donor DNA in the blood can help doctors better understand and detect heart transplant rejection in patients who are already having biopsies.

  Recruiting at 9 sites University of Alberta · Little Rock, Arkansas and 11 other locations · NCT04707872

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.