Evaluating heart health in adult survivors of childhood cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, prospective cohort study assesses early cardiac dysfunction in adult survivors of childhood cancer using advanced echocardiographic techniques. The study aims to determine if speckle tracking echocardiography can detect cardiac dysfunction earlier than conventional methods. Participants will undergo a comprehensive cardiac evaluation, including both standard and novel echocardiographic assessments, as well as cardiopulmonary exercise testing. The focus is on survivors who received cardiotoxic treatments, such as anthracyclines or chest radiation, to identify those at higher risk for cardiac issues.

Why it matters

Who can join: the full rules

This prospective cohort study is nested within the Childhood Cancer Registry (ChCR), a national, population-based cancer registry that includes all children and adolescents in Switzerland who were diagnosed with cancer at age 0-20 years. It includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumours or Langerhans cell histiocytosis. Childhood cancer survivors have survived at least 5 years from cancer diagnosis.

Inclusion Criteria:

* Registered in the ChCR
* Formerly treated at the Department of Pediatric Hematology/Oncology of one of five participating centers
* Treated with any chemotherapy and/or chest radiation
* Survived ≥ 5 years since most recent cancer diagnosis (primary cancer, relapse(s), secondary cancer) at time of examination
* Diagnosed at age ≤ 20 years
* ≥ 18 years of age at time of study participation
* Resident in Switzerland
* Written informed consent

Exclusion Criteria:

* Study participants will be excluded if they do not meet the above mentioned inclusion criteria or refuse to participate in the study.

Where it's running

• Department of Cardiology, University Hospital Basel
  Basel, Canton of Basel-City, Switzerland Recruiting
• Department of Cardiology, Inselspital Bern
  Bern, Switzerland Recruiting
• Department of Cardiology, University Hospitals of Geneva
  Geneva, Switzerland Recruiting
• Department of Cardiology, Lucerne Cantonal Hospital
  Lucerne, Switzerland Recruiting
• Department of Cardiology, Cantonal Hospital of St. Gallen
  Sankt Gallen, Switzerland Recruiting
• Institute of Social and Preventive Medicine, University of Bern
  Bern, Canton of Bern, Switzerland Active not recruiting

Study contacts

• Principal investigator: Claudia E Kuehni, MD — University of Bern
• Study coordinator: Claudia E Kuehni, MD
• Email: claudia.kuehni@unibe.ch
• Phone: +41 31 684 35 07

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.