Evaluating genetic factors in the development of collateral circulation in artery disease patients
Genome-wide Association Study of Development of Collateral Circulation for Patients With Coronary or Peripheral Artery Disease
Asan Medical Center · NCT05043948
This study is testing if certain genes affect how well blood vessels can grow around blocked arteries in patients with coronary or peripheral artery disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Asan Medical Center (other) |
| Locations | 1 site (Seoul) |
| Trial ID | NCT05043948 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the genetic associations related to the development of collateral circulation in patients suffering from coronary or peripheral artery disease. By analyzing blood samples, researchers will identify genetic markers that may influence the formation of collateral circulation, which is crucial for improving blood flow in affected individuals. The findings could lead to the development of molecular genetic treatment models based on the identified associations. The study focuses on patients with chronic total occlusive lesions as seen in angiograms.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over the age of 20 with chronic total occlusive lesions in coronary or peripheral arteries.
Not a fit: Patients with renal or hepatic dysfunction, recent major surgery plans, or a history of gastrointestinal hemorrhage may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized treatments that enhance collateral circulation, improving outcomes for patients with artery disease.
How similar studies have performed: While similar studies have explored genetic factors in cardiovascular conditions, this specific approach focusing on collateral circulation is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age more than 20 * Chronic total occlusive lesion from the coronary or peripheral angiogram Exclusion Criteria: * Renal dysfunction * Hepatic dysfunction * Thrombocythemia or thrombocythemia * Planned major surgery in 1 year * History of gastrointestinal haemorrhage * Malignant tumor
Where this trial is running
Seoul
- Asan Medical Center — Seoul, Korea, Republic of (RECRUITING)
Study contacts
- Study coordinator: Jung-hee Ham, Project manager
- Email: cvcrc5@amc.seoul.kr
- Phone: 82230104728
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Coronary Disease, Peripheral Arterial Disease, Collateral Circulation, Any Site, Genome-wide association, Collateral circulation