Evaluating food allergy thresholds and predictors
Official title: Thresholds In Food Allergy evaluaTion And predictioN, a Prospective, Multicentre Registry Study
Run by Hamilton Health Sciences Corporation · NCT06038019 · Data updated 2026-11-12
This study is trying to see how much of certain foods can trigger allergic reactions in people with food allergies in Canada and what factors might affect how severe those reactions are.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 3 Months to 65 Years |
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Hamilton Health Sciences Corporation Academic / other |
| Locations | 1 site (Hamilton, Ontario) |
| Status | Recruiting |
| Started | November 1, 2023 |
| Main results expected | November 1, 2050 |
| Study ends | January 1, 2051 |
| Registry record updated | June 3, 2024 |
| Trial ID | NCT06038019 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with a suspected or confirmed history of food allergies who can safely participate in oral food challenges.
✕Probably not a fit
Patients with previous desensitization treatment to food allergens or those with unstable medical conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational registry aims to quantify food allergy thresholds in Canada and identify their clinical predictors. Participants with a suspicion or history of food allergies will undergo oral food challenges to assess their reactions. The study will collect data on symptoms and test results to better understand the factors influencing food allergy severity. By analyzing this information, researchers hope to improve diagnosis and management of food allergies.
Why it matters
Potential benefit: If successful, this study could lead to better diagnosis and management strategies for patients with food allergies.
How similar studies have gone: Other studies have shown success in evaluating food allergy thresholds, indicating that this approach is supported by prior research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Suspicion or history of food allergy based on medical history, positive skin prick test, and/or serum food-specific IgE. A suggestive history is defined as typical clinical signs and/or symptoms (urticaria, angioedema, abdominal pain, vomiting, dyspnea, wheeze) within 60 minutes of the ingestion of a food. 2. Ability to discontinue all antihistamines for 1 week before oral food challenge. Exclusion Criteria: 1. Previous desensitization treatment to a food allergen 2. Allergies to any component of the oral challenge vehicle 3. Unstable conditions including uncontrolled asthma or chronic urticaria 4. Any clinically significant disease/chronic medical condition which may interfere with study evaluations.
Where it's running
-
McMaster University Medical Centre
Hamilton, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Derek Chu, MD PhD FRCPC — Hamilton Health Sciences & McMaster University
- Study coordinator: Heather Le
- Email: lehea@hhsc.ca
- Phone: 905-525-9140
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study will test whether higher, weight-based doses of omalizumab are safe and help people with food allergies, including those with very high allergic antibody (IgE) levels, tolerate their allergens better.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.