Oral immunotherapy for children with cashew nut allergies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effectiveness of oral immunotherapy (OIT) specifically for children aged 6 months to 17 years who are allergic to cashew nuts. The approach involves gradually introducing cashew nuts to increase tolerance and potentially achieve desensitization. The study aims to address the rising incidence of severe allergic reactions to cashew nuts in Finland, where traditional avoidance strategies have proven insufficient. Participants will undergo a positive oral food challenge to confirm their allergy before starting the treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 6 months - 17 years
2. Sensitization to cashew nut (allergen-specific IgE or positive skin PRICK test)
3. Positive oral food challenge for cashew nut

Exclusion Criteria:

1. Poor adherence
2. Uncontrolled or severe asthma
3. Uncontrolled active or severe or atopic dermatitis
4. Chronic urticaria
5. Eosinophilic esophagitis or other gastrointestinal eosinophilic disorders
6. Active malignant neoplasia
7. Active systemic, autoimmune disease
8. Diabetes treated with insulin
9. Severe systemic illness or severe medical conditions such as cardiovascular or lung diseases
10. Medication with beta blockers
11. Medication with ACE-inhibitors
12. Mastocytosis
13. Pregnancy or breastfeeding
14. Language barriers (not fluent Finnish or Swedish)

Where it's running

• HUS Skin and Allergy Hospital
  Helsinki, Finland Recruiting

Study contacts

• Study coordinator: Heidi Sandström, MD
• Email: heidi.sandstrom@hus.fi
• Phone: +358 50 428 7931

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.